{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:28:32Z","timestamp":1790760512000,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In order to realize the early diagnosis of Alzheimer's disease (AD), we designed and synthesized a series of multi\u2010fluorine labeled indanone derivatives based on indanone which could target \u03b2\u2010amyloid (A\u03b2). Through the in vitro staining experiment and affinity experiment, we selected <jats:bold>7d<\/jats:bold> out, and then evaluated it through other in vivo and in vitro experiments. The staining of AD human brain adjacent sections revealed that compound <jats:bold>7d<\/jats:bold> could bind to A\u03b2 plaques with high affinity. In the in vitro binding assay, <jats:bold>7d<\/jats:bold> showed a balanced affinity with A\u03b21\u201340 (<jats:italic>K<\/jats:italic><jats:sub>d<\/jats:sub> =\u2009367\u2009\u00b1\u200913) and A\u03b21\u201342 (<jats:italic>K<\/jats:italic><jats:sub>d<\/jats:sub> =\u2009384\u2009\u00b1\u200956). Also, <jats:bold>7d<\/jats:bold> exhibited a low toxicity (LD50\u2009&gt;\u200950\u2009mg\/kg) and an excellent ability to pass through the blood\u2013brain barrier (Log <jats:italic>p<\/jats:italic>\u2009=\u20093.87). The biodistribution experiment in mice showed that <jats:bold>7d<\/jats:bold> reached the highest brain uptake after 1 h of tail vein injection and cleared after 24\u2009h. A low concentration of <jats:bold>7d<\/jats:bold> (1.875\u2009mg\/ml) showed a strong imaging ability (19F\u2010weighted mode), and the imaging capability increased with the increasing of concentration. All the results showed that <jats:bold>7d<\/jats:bold> could provide a feasible solution for the early diagnosis of AD under non\u2010radioactive condition.<\/jats:p>","DOI":"10.1111\/cbdd.14162","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T13:38:53Z","timestamp":1666877933000},"page":"650-661","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Multi\u2010fluorine labeled indanone derivatives as potential <scp>MRI<\/scp> imaging probes for <scp>\u03b2\u2010Amyloid<\/scp> plaques"],"prefix":"10.1111","volume":"101","author":[{"given":"Yaqian","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory The First Affiliated Hospital of Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tangni","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory The First Affiliated Hospital of Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanhong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory The First Affiliated Hospital of Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taoshan","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Life Sciences Anhui Agricultural University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinping","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory The First Affiliated Hospital of Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,25]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"2020 Alzheimer's Disease Facts and Figures[EB\/OL]. 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