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The search for novel anticancer active agents with a broader cytotoxicity range is therefore continuously ongoing. The benzene ring gets fused to a pyridine ring at two carbon atoms close to one another to form the double ring structure of the heterocyclic aromatic nitrogen molecule known as quinoline (1\u2010azanaphthalene). Quinoline derivatives contain a wide range of pharmacological activities, including antitubercular, antifungal, antibacterial, and antimalarial properties. Quinoline derivatives have also been shown to have anticancer properties. There are many quinoline derivatives widely available as anticancer drugs that act via a variety of mechanisms on various molecular targets, such as inhibition of topoisomerase, inhibition of tyrosine kinases, inhibition of heat shock protein 90 (Hsp90), inhibition of histone deacetylases (HDACs), inhibition of cell cycle arrest and apoptosis, and inhibition of tubulin polymerization.<\/jats:p>","DOI":"10.1111\/cbdd.14196","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T08:30:13Z","timestamp":1671438613000},"page":"977-997","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Molecular target interactions of quinoline derivatives as anticancer agents: A review"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2390-4056","authenticated-orcid":false,"given":"Vikas","family":"Pradhan","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry Noida Institute of Engineering and Technology (Pharmacy Institute)  Greater Noida India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1868-8865","authenticated-orcid":false,"given":"Salahuddin","family":"\u00a0","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Noida Institute of Engineering and Technology (Pharmacy Institute)  Greater Noida India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajnish","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Noida Institute of Engineering and Technology (Pharmacy Institute)  Greater Noida India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avijit","family":"Mazumder","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Noida Institute of Engineering and Technology (Pharmacy Institute)  Greater Noida India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Mustaqeem","family":"Abdullah","sequence":"additional","affiliation":[{"name":"A N A Institute of Pharmaceutical Sciences and Research  Bareilly India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9298-0154","authenticated-orcid":false,"given":"Mohammad","family":"Shahar\u00a0Yar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry School of Pharmaceutical Education and Research, Jamia Hamdard  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Jawed","family":"Ahsan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Maharishi Arvind College of Pharmacy  Jaipur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zabih","family":"Ullah","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Dentistry and Pharmacy, Buraydah Colleges  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2018.10.064"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.07.044"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.3202"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.02.058"},{"key":"e_1_2_7_6_1","first-page":"173","article-title":"Evaluation of miscellaneous heat shock protein (Hsp90) inhibitors using different methodologies","volume":"5","author":"Al\u2010Sha'er M. 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