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Among the novel targets, <jats:italic>Plasmodium falciparum<\/jats:italic> autophagy\u2010related proteins (<jats:italic>Pf<\/jats:italic>Atg) remain a priority. In this paper, we reviewed the existing knowledge on the functions and structural biology of <jats:italic>Pf<\/jats:italic>Atg including the compounds with inhibitory activity toward <jats:italic>P<\/jats:italic>.\u00a0<jats:italic>falciparum<\/jats:italic> Atg8\u2010Atg3 protein\u2013protein interaction (<jats:italic>Pf<\/jats:italic>Atg8\u2010<jats:italic>Pf<\/jats:italic>Atg3 PPI). A total of five <jats:italic>Pf<\/jats:italic>Atg (<jats:italic>Pf<\/jats:italic>Atg5, <jats:italic>Pf<\/jats:italic>Atg8, <jats:italic>Pf<\/jats:italic>Atg12, <jats:italic>Pf<\/jats:italic>Atg18, and Rab7) were observed to have autophagic and\/or non\u2010autophagic roles. Available data showed that <jats:italic>Pf<\/jats:italic>Atg8 has conserved hydrophobic pockets, which allows it to interact with <jats:italic>Pf<\/jats:italic>Atg3 to form <jats:italic>Pf<\/jats:italic>Atg8\u2010<jats:italic>Pf<\/jats:italic>Atg3 PPI. Additionally, 2\u2010bromo\u2010N\u2010(4\u2010pyridin\u20102\u2010yl\u20101,3\u2010thiazol\u20102\u2010yl) benzamide was identified as the most powerful inhibitor of <jats:italic>Pf<\/jats:italic>Atg8\u2010<jats:italic>Pf<\/jats:italic>Atg3 PPI. Due to the dearth of knowledge in this field, we hope that the article would open an avenue to further research on the remaining <jats:italic>Pf<\/jats:italic>Atg as possible drug candidates.<\/jats:p>","DOI":"10.1111\/cbdd.14225","type":"journal-article","created":{"date-parts":[[2023,3,4]],"date-time":"2023-03-04T05:34:25Z","timestamp":1677908065000},"page":"1241-1251","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Biological functions and structural biology of <i>Plasmodium falciparum<\/i> autophagy\u2010related proteins: The under\u2010explored options for novel antimalarial drug design"],"prefix":"10.1111","volume":"101","author":[{"given":"Mohammed Aliyu","family":"Usman","sequence":"first","affiliation":[{"name":"Department of Biochemistry Ahmadu Bello University  Zaria Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulmalik 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