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Therefore, the present study was conducted to elucidate the protective effect of lariciresinol, a lignan, against Complete Freund's adjuvant (CFA)\u2010induced arthritis in rats. The results of the study showed that lariciresinol improves paw swelling and arthritic scores in rats as compared to CFA rats. Lariciresinol also showed a significant reduction in rheumatoid factor, C\u2010reactive protein, tumor necrosis factor\u2010\u03b1, interleukin (IL)\u201017, and tissue inhibitor of metalloproteinases\u20103 level with a simultaneous increase in IL\u20104 level. The burden of oxidative stress was also reduced in CFA rats, as shown by reduced MDA levels and increased SOD and GPx after the administration of lariciresinol. In a Western blot analysis, lariciresinol showed a significant reduction of transforming growth factor\u2010\u03b2 and nuclear factor\u2010\u03baB (NF\u2010\u03baB) protein levels in CFA rats. To understand the binding characteristic of lariciresinol with NF\u2010\u03baB, molecular docking analysis was conducted, which showed Larciresinol interacted with the active site of NF\u2010\u03baB. Our study demonstrated the significant protective effect of lariciresinol against RA via multi\u2010target action.<\/jats:p>","DOI":"10.1111\/cbdd.14268","type":"journal-article","created":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T02:19:15Z","timestamp":1684721955000},"page":"168-176","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Lariciresinol protects rats from complete Freund's adjuvant induced arthritis in rats via modulation of transforming growth factor\u2010\u03b2 and nuclear factor kappa B pathway: An in vivo and in silico study"],"prefix":"10.1111","volume":"102","author":[{"given":"Xiangzhuo","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Rheumatic Immunology Xingtai People's Hospital  Xingtai Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatic Immunology Xingtai People's Hospital  Xingtai Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronghua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatic Immunology Xingtai People's Hospital  Xingtai Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingfang","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Rheumatic Immunology Xingtai People's Hospital  Xingtai Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatic Immunology Xingtai People's Hospital  Xingtai Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianju","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatic Immunology Xingtai People's Hospital  Xingtai Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.13103"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep46035"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2005.09.012"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20103083.2011.04415.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0260356"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/WOX.0b013e3182439613"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.08.024"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000493390"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(17)31491\u20105"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/rrcc.s16919"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-801238-3.65249-2"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph12020068"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.118.2.503"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23123251"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753\u2010012\u20109483\u20100"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.02.006"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2018.3649"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.223545"},{"key":"e_1_2_9_20_1","doi-asserted-by":"crossref","unstructured":"Hepel M. &Andreescu S.(2015).Oxidative stress and human health. 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