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Untreated, it poses a hazard to civilization since it can lead to terrifying consequences and even death. Oral hypoglycemic medicines presently available act in a variety of ways, targeting various organs and pathways. The use of protein tyrosine phosphatase 1B (PTP1B) inhibitors, on the contrary, is a novel and effective method of controlling type 2 diabetes. PTP1B is a negative insulin signaling pathway regulator; hence, inhibiting PTP1B increases insulin sensitivity, glucose absorption, and energy expenditure. PTP1B inhibitors also restore leptin signaling and are considered a potential obesity target. In this review, we have compiled a summary of the most recent advances in synthetic PTP1B inhibitors from 2015 to 2022 which have scope to be developed as clinical antidiabetic drugs.<\/jats:p>","DOI":"10.1111\/cbdd.14275","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T05:55:56Z","timestamp":1685080556000},"page":"921-938","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["A comprehensive review on the research progress of <scp>PTP1B<\/scp> inhibitors as antidiabetics"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7575-3670","authenticated-orcid":false,"given":"Neetu","family":"Agrawal","sequence":"first","affiliation":[{"name":"Institute of Pharmaceutical Research GLA University  Mathura Uttar Pradesh 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