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In comparison with other heterocyclic moieties, 1,2,5\u2010oxadiazoles moiety is considered as underprivileged as it attracted little attention of the researchers although lot of scopes and possible applications in medicinal, material and agriculture science. 1,2,5\u2010oxadiazole and its derivatives have been reported as good pharmacophores as carbonic anhydrase inhibitors, antibacterial, vasodilating agents, antimalarial, anticancer, etc. In the presented manuscript, we reviewed granted patents and different synthetic strategies which have been reported for the synthesis of 1,2,5\u2010oxadiazoles such as cycloaddition, dimerization, cyclodehydration, condensation, thermolysis, nitration, oxidation and ring\u2010conversion. These synthetic methods have also been analysed for their merits and demerits. The manuscript also highlighted various applications of 1,2,5\u2010oxadiazole and its derivatives. We hope that researchers across the scientific streams will be benefitted from the presented review articles for designing their work related to 1,2,5\u2010oxadiazoles.<\/jats:p>","DOI":"10.1111\/cbdd.14276","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:52:56Z","timestamp":1686185576000},"page":"907-920","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Synthetic approaches and applications of an underprivileged 1,2,5\u2010oxadiazole moiety: A review"],"prefix":"10.1111","volume":"102","author":[{"given":"Greesh","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry Noida Institute of Engineering and Technology (Pharmacy Institute)  Greater Noida India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajnish","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Noida Institute of Engineering and Technology (Pharmacy Institute)  Greater Noida India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avijit","family":"Mazumder","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Noida Institute of Engineering and Technology (Pharmacy Institute)  Greater Noida India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Salahuddin","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Noida Institute of Engineering and Technology (Pharmacy Institute)  Greater Noida India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Upendra","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Noida Institute of Engineering and Technology (Pharmacy Institute)  Greater Noida India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2005.05.020"},{"key":"e_1_2_8_3_1","unstructured":"Andrew P. &Eddy W.(2011).Treatment of Cancer combs Yue. 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