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The interplay between pathogenic factors such as increased oxidative stress, neuroinflammation, mitochondrial dysfunction and apoptosis are responsible for neurodegeneration in PD. Intrastriatal administration of 6\u2010hydroxy dopamine (6\u2010OHDA) in rat brain provoked oxidative and nitrosative stress by decreasing endogenous antioxidants such as superoxide dismutase, catalase, glutathione, glutathione peroxidase and glutathione reductase. Consequently, interleukin\u20106, tumour necrosis\u2010\u03b1, interferon\u2010\u03b3 and cyclooxygenase\u20102 mediated neuroinflammation leads to mitochondrial dysfunction, involving inhibition of complex\u2010II and IV activities, followed by apoptosis and degeneration of striatal dopaminergic neurons. Degeneration of dopaminergic neurons resulted in reduced dopamine turnover, consequently induced behavioural abnormalities in rats. Activation of peroxisome proliferator\u2010activated receptors (PPARs) have protective role in PD by modulating response of antioxidant enzymes, neuroinflammation and apoptosis in various animal models of PD. Saroglitazar (SG) being dual PPAR\u2010\u03b1\/\u03b3 agonist activates both PPAR\u2010\u03b1 and PPAR\u2010\u03b3 receptors and provide neuroprotection by reducing oxidative stress, neuroinflammation, mitochondrial dysfunction and apoptosis of dopaminergic cells in 6\u2010OHDA induced PD in rats. Thereby, SG restored striatal histopathological damage and dopamine concentration in rat striatum, and behavioural alterations in rats. Thus, SG proved neuroprotective effects in rat model of PD. Potential benefits of SG in rat model of PD advocates to consider it for further preclinical and clinical evaluation.<\/jats:p>","DOI":"10.1111\/cbdd.14306","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T02:26:35Z","timestamp":1690770395000},"page":"955-971","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Neuroprotective potential of saroglitazar in <scp>6\u2010OHDA<\/scp> induced Parkinson's disease in rats"],"prefix":"10.1111","volume":"102","author":[{"given":"Rohit","family":"Bhatt","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences Saurashtra University  Rajkot India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devendra","family":"Vaishnav","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Saurashtra University  Rajkot 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