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Towards this, the effect of DEX was first evaluated on the infarct size and the histopathology of cardiac tissues using TTC and H and E staining, and it was found that DEX significantly improved the infarct size and architecture of the myocardial tissues following the I\/R injury. DEX also showed significant improvement in various examined hemodynamic parameters (e.g., LVSP, and\u2009\u00b1\u2009dp\/dt<jats:sub>max<\/jats:sub>) in a dose\u2010dependent manner. The lipid profile (LDL, VLDL, TC, TG, and HDL level) of the rats were also found significantly improved in DEX\u2010treated rats. The level of various pro\u2010inflammatory cytokines (IL\u20101\u03b2, IL\u20106, IL\u201010, IL\u201017, and TNF\u2010\u03b1), cardiac injury (CK, CK\u2010MB, Troponin I AST, ALT, and LDH), and oxidative stress (MDA, SOD, and GSH) biomarkers were also found to be restored near to the normal in DEX\u2010treated group. It has been found that DEX also significantly reduces apoptosis of rat cardiomyocytes. In western blot analysis, DEX showed a significant reduction in the activation of NF\u2010\u03baB. In conclusion, our study demonstrated the protective effect of Dexmedetomidine in myocardial ischemia\u2013reperfusion injury in hyperlipidemic rats possibly via amelioration of oxidative stress, and inflammation apoptosis.<\/jats:p>","DOI":"10.1111\/cbdd.14324","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T10:00:52Z","timestamp":1692698452000},"page":"1176-1185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Dexmedetomidine attenuates myocardial ischemia\u2013reperfusion injury in hyperlipidemic rats by inhibiting inflammation, oxidative stress and NF\u2010\u03baB"],"prefix":"10.1111","volume":"102","author":[{"given":"Weiwei","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Anesthesiology The First Hospital of Hebei Medical University  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First Hospital of Hebei Medical University  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Li","sequence":"additional","affiliation":[{"name":"Operating Center The First Hospital of Hebei Medical University  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yating","family":"Li","sequence":"additional","affiliation":[{"name":"Pharmacy Intravenous Admixture Services The First Hospital of Hebei Medical University  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfang","family":"Wu","sequence":"additional","affiliation":[{"name":"Operating Center The First Hospital of Hebei Medical University  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First Hospital of Hebei Medical University  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First Hospital of Hebei Medical University  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.37648\/ijrst.v12i01.005"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.01.081"},{"key":"e_1_2_10_4_1","first-page":"231","article-title":"Cardiac markers in the early diagnosis and management of patients with acute coronary syndrome","volume":"9","author":"Al\u2010Hadi H. 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