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Preliminary therapeutics becoming ineffective that might lead to noteworthy mortality presents a crucial challenge for the scientific community. Hence, there is an urgent need to develop hybrid compounds as antimicrobial agents by combining two or more bioactive heterocyclic moieties into a single molecular framework with fewer side effects and a unique mode of action. This review highlights the recent advances (2013\u20132023) in the pharmacology of rhodanine\u2010linked quinoline hybrids as more effective antimicrobial agents. In the drug development process, linker hybrids acquire the top position due to their excellent \u03c0\u2010stacking and Van der Waals interaction with the DNA active sites of pathogens. A molecular hybridization strategy has been optimized, indicating that combining these two bioactive moieties with an arylidene and an amino spacer linker increases the antimicrobial potential and reduces drug resistance. Moreover, the structure\u2013activity relationship study is discussed to express the role of various functional groups in improving and decrementing antimicrobial activities for rational drug design. Also, a linker approach may accelerate the development of dynamic antimicrobial agents through molecular hybridization.<\/jats:p>","DOI":"10.1111\/cbdd.14345","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T07:37:35Z","timestamp":1694504255000},"page":"1632-1642","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Arylidene and amino spacer\u2010linked rhodanine\u2010quinoline hybrids as upgraded antimicrobial agents"],"prefix":"10.1111","volume":"102","author":[{"given":"Zebabanu","family":"Khalifa","sequence":"first","affiliation":[{"name":"Department of Chemistry Government College, Daman (Affiliated to Veer Narmad South Gujarat University, Surat)  Daman India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachana","family":"Upadhyay","sequence":"additional","affiliation":[{"name":"Department of Chemistry Government College, Daman (Affiliated to Veer Narmad 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