{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:01:27Z","timestamp":1789038087618,"version":"build-2803163510"},"reference-count":68,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Psoriasis is a chronic inflammatory skin disease that affects both localized and systemic regions of the body. This condition is characterized by the hyperproliferation of keratinocytes, resulting in skin thickening, scaling, and erythema. The severity of psoriasis depends on the extent of skin involvement, the location of the infection, and the symptoms that the person exhibits. While no cure exists, conventional therapies such as topical and systemic drugs are generally used to manage the exacerbation of symptoms. However, chronic use and overdose can lead to other severe adverse effects. Therefore, scientists and researchers are exploring potential nutraceuticals that can be considered as an alternative source of management for psoriasis. Current research aims to use different combinations of natural compounds like cannabidiol, myo\u2010inositol, eicosapentaenoic acid, and krill oil to study the effect of these compounds in the prevention and treatment of psoriasis in the imiquimod (IMQ)\u2010induced psoriatic mice model. The Psoriasis Area Severity Index (PASI) scoring system is used to analyze skin thickness, scales, and erythema. The results indicate that the krill oil combined with the cannabidiol and myo\u2010inositol shows better results than other nutraceutical combinations. In the future, the natural products of krill oil can be combined with cannabidiol and myo\u2010inositol to create an improved alternative to existing steroidal and nonsteroidal anti\u2010inflammatory drugs for psoriasis treatment.<\/jats:p>","DOI":"10.1111\/cbdd.14350","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T03:34:09Z","timestamp":1694662449000},"page":"1578-1587","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Nutraceutical combination ameliorates imiquimod\u2010induced psoriasis in mice"],"prefix":"10.1111","volume":"102","author":[{"given":"Singaravel","family":"Vijayapoopathi","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry, Dr. ALM Post\u2010Graduation Institute of Basic Medical Sciences University of Madras  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajalakshmi","family":"Ramamoorthy","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Dr. ALM Post\u2010Graduation Institute of Basic Medical Sciences University of Madras  Chennai India"},{"name":"Department of Obstetrics, Gynecology and Reproductive Studies University of Miami  Coral Gables Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayaprakash","family":"Meganathan","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Dr. ALM Post\u2010Graduation Institute of Basic Medical Sciences University of Madras  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ananthi","family":"Kalaiyazhagan","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Dr. ALM Post\u2010Graduation Institute of Basic Medical Sciences University of Madras  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sridharan","family":"Bhuvarahamurthy","sequence":"additional","affiliation":[{"name":"Boston University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhuvarahamurthy","family":"Venugopal","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Dr. ALM Post\u2010Graduation Institute of Basic Medical Sciences University of Madras  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/1028415X.2019.1659560"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9010021"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S17220"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13072210"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477\u20107525\u20104\u201035"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21676"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.591803"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(14)61909\u20107"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/md15030074"},{"key":"e_1_2_10_11_1","first-page":"291","volume-title":"Autophagy: Cancer, other pathologies, inflammation, immunity, infection, and aging","author":"Bonofiglio D.","year":"2016"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh094"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2012.15"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102133.2002.04996.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcme.2020.03.005"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuz098"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2015.09.012"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2019.106635"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idairyj.2009.11.015"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102688"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2011.07.006"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700807"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2021.06.006"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102474\u201011\u2010136"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20160645"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/diseases7010015"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781315152912-18"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906\u2010016\u20101311\u2010x"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0190\u20109622(88)70133\u20104"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S220053"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2021.05.016"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.31138\/mjr.31.2.190"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.790712"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/1750\u20103841.14044"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/sigtrans.2017.23"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010020\u201002892\u20101"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.07.046"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370216647183"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c06949"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20194851"},{"key":"e_1_2_10_41_1","volume-title":"Global report on psoriasis","author":"Michalek I. M.","year":"2016"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13854"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000137191.02577.86"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2014.08.003"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804595"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20103083.2011.03990.x"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2017.07.024"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18215"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctcp.2018.01.007"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075\u2010017\u20101249\u20105"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20061475"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14712"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229\u20105178.193908"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2021.02.755"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aag2791"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro\u20102021\u20100118"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2023.109348"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313608"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.911347"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389450116666150107152206"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944\u2010017\u20100601\u20108"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14020368"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346\u20108138.12367"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802999"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/1541\u20104337.12427"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24112157"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S331154"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.btre.2019.e00341"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2021.104394"}],"container-title":["Chemical Biology &amp; Drug Design"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cbdd.14350","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T12:21:56Z","timestamp":1699446116000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cbdd.14350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,13]]},"references-count":68,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/cbdd.14350"],"URL":"https:\/\/doi.org\/10.1111\/cbdd.14350","archive":["Portico"],"relation":{},"ISSN":["1747-0277","1747-0285"],"issn-type":[{"value":"1747-0277","type":"print"},{"value":"1747-0285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,13]]},"assertion":[{"value":"2023-05-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}