{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T18:43:21Z","timestamp":1780425801572,"version":"3.54.1"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006342","name":"Association Vaincre la Mucoviscidose","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006342","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004584","name":"Conseil R\u00e9gional de Bretagne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004584","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004923","name":"AFM-T\u00e9l\u00e9thon","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ovarian cancer is the seventh most frequently diagnosed cancer among women worldwide. Most patients experience recurrence and succumb eventually to resistant disease, underscoring the need for an alternative treatment option. In the presented manuscript, we investigated the effect of the TRAIL\u2010gene, transfected by an innovative bioinspired lipid vector BSV163\/DOPE in the presence or absence of cisplatin, to fight against sensitive and resistant ovarian cancer. We showed that BSV163\/DOPE can transfect ovarian cancer cell lines (Caov3, OVCAR3, and our new cisplatin\u2010resistant, CR\u2010Caov3) safely and efficiently. In addition, TRAIL\u2010gene transfection in association with cisplatin inhibited cellular growth more efficiently (nearly 50% in Caov3 cells after the combined treatment, and 15% or 25% by each treatment alone, respectively) owing to an increase in apoptosis rate, caspases activity and TRAIL's death receptors expression. Most importantly, such synergistic effect was also observed in CR\u2010Caov3 cells demonstrated by an apoptosis rate of 35% following the combined treatment in comparison with 17% after TRAIL\u2010gene transfection or 6% after cisplatin exposition. These results suggest this combination may have potential application for sensitive as well as refractory ovarian cancer patients.<\/jats:p>","DOI":"10.1111\/cbdd.14357","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T04:10:31Z","timestamp":1695269431000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["BSV163\/DOPE\u2010mediated TRAIL gene transfection acts synergistically with chemotherapy against cisplatin\u2010resistant ovarian cancer"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1997-0413","authenticated-orcid":false,"given":"Quoc Manh","family":"Nguyen","sequence":"first","affiliation":[{"name":"Univ Brest, Inserm, EFS, UMR 1078, GGB, GTCA Team, \u201cGene Transfer and Combined therapeutic Approaches\u201d  Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Fran\u00e7ois","family":"Dupr\u00e9","sequence":"additional","affiliation":[{"name":"Univ Brest, Inserm, EFS, UMR 1078, GGB, GTCA Team, \u201cGene Transfer and Combined therapeutic Approaches\u201d  Brest France"},{"name":"CHU de Brest, Service de Chirurgie Gyn\u00e9cologique  Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Berchel","sequence":"additional","affiliation":[{"name":"Univ Brest, CNRS, CEMCA UMR 6521  Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosy","family":"Ghanem","sequence":"additional","affiliation":[{"name":"Univ Brest, Inserm, EFS, UMR 1078, GGB, GTCA Team, \u201cGene Transfer and Combined therapeutic Approaches\u201d  Brest France"},{"name":"CHU de Brest, Service de G\u00e9n\u00e9tique M\u00e9dicale et de Biologie de la Reproduction  Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul\u2010Alain","family":"Jaffr\u00e8s","sequence":"additional","affiliation":[{"name":"Univ Brest, CNRS, CEMCA UMR 6521  Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9rique","family":"d'Arbonneau","sequence":"additional","affiliation":[{"name":"Univ Brest, Inserm, EFS, UMR 1078, GGB, GTCA Team, \u201cGene Transfer and Combined therapeutic Approaches\u201d  Brest France"},{"name":"CHU de Brest, Service d'Odontologie, UFR d'Odontologie de Brest  Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Montier","sequence":"additional","affiliation":[{"name":"Univ Brest, Inserm, EFS, UMR 1078, GGB, GTCA Team, \u201cGene Transfer and Combined therapeutic Approaches\u201d  Brest France"},{"name":"CHU de Brest, Service de G\u00e9n\u00e9tique M\u00e9dicale et de Biologie de la Reproduction  Brest France"},{"name":"CHU de Brest, Centre de R\u00e9f\u00e9rence des Maladies Rares \u201cMaladies Neuromusculaires\u201d  Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14205125"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2003.11.054"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19071930"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/c9ob00473d"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9OB02381J"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.20892\/j.issn.2095\u20103941.2016.0084"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes13081370"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30676"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc\u20102017\u20100308"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u201061779\u2010207\u20106_2"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.05.004"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3126"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23140"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.84"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2009.09.014"},{"issue":"4","key":"e_1_2_11_17_1","first-page":"288","article-title":"Recurrent epithelial ovarian cancer: An update on treatment","volume":"27","author":"Foley O. W.","year":"2013","journal-title":"Oncology (Williston Park, NY)"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2022.122491"},{"issue":"144","key":"e_1_2_11_19_1","first-page":"219","article-title":"New developments in molecular targeted therapy of ovarian cancer","volume":"26","author":"Guan L. Y.","year":"2018","journal-title":"Discovery Medicine"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep23764"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2009.06.012"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1615396113"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26247507"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201403103"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2021.03.012"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2012.926"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2017.5818"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14011477"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401855"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010immunol\u2010042617\u2010053010"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41417\u2010023\u201000590\u20106"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280\u2010015\u20102712\u20100"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.04.060"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571\u2010020\u20100339\u20105"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon\u20102020\u20100727"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0232565"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2017.28"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2011.130"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01287"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/prot.24193"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.11.023"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.368282"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401\u2010019\u20100287\u20108"}],"container-title":["Chemical Biology &amp; Drug Design"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cbdd.14357","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T06:17:49Z","timestamp":1731737869000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cbdd.14357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,20]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/cbdd.14357"],"URL":"https:\/\/doi.org\/10.1111\/cbdd.14357","archive":["Portico"],"relation":{},"ISSN":["1747-0277","1747-0285"],"issn-type":[{"value":"1747-0277","type":"print"},{"value":"1747-0285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,20]]},"assertion":[{"value":"2023-05-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14357"}}