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The neurotransmitter levels, including substance P (SP), motilin (MTL), 5\u2010hydroxytryptamine (5\u2010HT), and vasoactive intestinal peptide (VIP), were determined by ELISA methods. The stem cell factors (SCF)\/c\u2010Kit signaling pathway\u2010related protein and mRNA levels were determined by western blot and reverse transcription quantitative polymerase chain reaction (RT\u2010qPCR) analyses, respectively. The expressions of tight ZO\u20101, Occludin, and Claudin\u20101 were also measured by western blot assay and immunofluorescence staining. The 16S rRNA gene sequence was used to measure the composition of gut microbiota. The co\u2010administration of FE and SH improved the body weight, number of fecal pellets, fecal moisture, abdominal with drawal reflex score, and gastrointestinal transit rate in IBS\u2010C rats. The unique efficacy of combination depended on the regulation of balance between excitatory and inhibitory neurotransmitters, enhancement of intestinal barrier function, and activation of SCF\/c\u2010Kit pathway. The gut microbiota structure was also restored. The ability of FE combined with SH to regulate SCF\/c\u2010Kit signaling pathway, enhance intestinal barrier function, and modulate gut microbiota contributes to their efficacy in managing IBS\u2010C in rats.<\/jats:p>","DOI":"10.1111\/cbdd.14397","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T02:00:26Z","timestamp":1701309626000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Combination of fenchone and sodium hyaluronate ameliorated constipation\u2010predominant irritable bowel syndrome and underlying mechanisms"],"prefix":"10.1111","volume":"103","author":[{"given":"Li","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine Nanjing University of Chinese Medicine Nanjing 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