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In this study, we employed a combined strategy involving molecular docking\u2010based virtual screening, molecular dynamics (MD) simulation, and molecular mechanics\/generalized Born surface area (MM\/GBSA) free energy calculation on existing FDA\u2010approved drugs. Six compounds were selected for further experimental assay: vemurafenib, sorafenib, sildenafil, fluvastatin, erlotinib, and glimepiride. Among these compounds, sorafenib and glimepiride exhibited significant inhibition of myeloma cell proliferation in the RPMI\u20108226 cell line. Moreover, both compounds simultaneously downregulated c\u2010Maf protein expression to induce G1 phase arrest and apoptosis in myeloma cells. Collectively, sorafenib and glimepiride may be considered promising candidates for developing more potent c\u2010Maf inhibitors in the future.<\/jats:p>","DOI":"10.1111\/cbdd.14403","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T12:55:00Z","timestamp":1700571300000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Discovery of small molecule <scp>c\u2010Maf<\/scp> inhibitors using molecular docking\u2010based virtual screening, molecular dynamics simulation, and biological evaluation"],"prefix":"10.1111","volume":"103","author":[{"given":"Zhiwei","family":"Hu","sequence":"first","affiliation":[{"name":"College of Medical Imaging Xuzhou Medical University Xuzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yindi","family":"Zeng","sequence":"additional","affiliation":[{"name":"Blood Diseases Institute Xuzhou Medical University Xuzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Blood Diseases Institute Xuzhou Medical University Xuzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiurong","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Xuzhou Medical University Xuzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinge","family":"Xu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Xuzhou Medical University Xuzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Medical Imaging Xuzhou Medical University Xuzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v99.6.2185"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1132"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20290"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2004.05.004"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/c6cp03670h"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.065896.118"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10822\u2010019\u201000193\u20100"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20215410"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401\u2010019\u20100249\u20101"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00894\u2010022\u201005261\u20101"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.10349"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00894\u2010022\u201005082\u20102"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21666"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1535\u20106108(04)00019\u20104"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2022.215791"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102007\u201005\u2010088666"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1011442"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102016\u201003\u2010706077"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.791885"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphys.2021.111108"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/c4cp01388c"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964\u2010020\u201000676\u2010w"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20035"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.450"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky427"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp404160y"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020005199"}],"container-title":["Chemical Biology &amp; 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