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SARS\u2010CoV\u20102 main protein (M<jats:sup>pro<\/jats:sup>) is a special cysteine protease that is a key enzyme for SARS\u2010CoV\u20102 replication. It is encoded by peptides and is responsible for processing peptides into functional proteins, making it an important drug target. The paper reviews the structure and peptide\u2010like inhibitors of SARS\u2010CoV\u20102 M<jats:sup>pro<\/jats:sup>, also the binding mode and structure\u2013activity relationship between the inhibitors and M<jats:sup>pro<\/jats:sup> are introduced in detail. 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