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Phillygenin increased survival rate, reduced W\/D ratio, and lung injury score, and inhibited IL\u20101\u03b2, IL\u20106, TNF\u2010\u03b1, and INF\u2010\u03b3 levels in mice model of bronchopneumonia. Remimazolam induced PDPK1 and p\u2010AKT protein expressions, and suppressed NLRP3 protein expression in lung tissue of mice model. In\u00a0vitro model, Remimazolam also induced PDPK1 and p\u2010AKT protein expressions, and suppressed NLRP3 protein expression. Remimazolam also inhibited inflammation levels in\u00a0vitro model. PDPK1 inhibitor, PHT\u2010427 (100\u2009mg\/kg) reduced survival rate, increased W\/D ratio and lung injury score, and promoted inflammation levels in mice model of bronchopneumonia by treated with Remimazolam. PHT\u2010427 suppressed PDPK1 and p\u2010AKT protein expressions and induced NLRP3 protein expression in mice model of bronchopneumonia by treated with Remimazolam. Remimazolam interlinked PDPK1 protein. Remimazolam increased the expressions of PDPK1 and p\u2010AKT in\u00a0vitro model. Remimazolam reduced PDPK1 ubiquitination in\u00a0vitro model.<\/jats:p>","DOI":"10.1111\/cbdd.14438","type":"journal-article","created":{"date-parts":[[2024,1,6]],"date-time":"2024-01-06T02:56:18Z","timestamp":1704509778000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Remimazolam attenuates inflammation in bronchopneumonia through the inhibition of <scp>NLRP3<\/scp> activity by <scp>PDPK1<\/scp> ubiquitination"],"prefix":"10.1111","volume":"103","author":[{"given":"Min","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture  Enshi City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture  Enshi City China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16157"},{"key":"e_1_2_7_3_1","first-page":"845","article-title":"Laboratory investigation of cases of fatal bacterial pneumonia in dairy cows","volume":"63","author":"Burrows D.","year":"2022","journal-title":"The Canadian Veterinary Journal"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16091"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbr.2021.07.008"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916934.2021.1891534"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.103979"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11050391"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16005"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108331"},{"key":"e_1_2_7_11_1","first-page":"94","article-title":"Clinical value of atomization therapy in children with bronchopneumonia","volume":"74","author":"Han X.","year":"2022","journal-title":"Minerva Pediatr (Torino)"},{"key":"e_1_2_7_12_1","first-page":"168","article-title":"Antibiotic therapy of postoperative bronchopneumonia in patients after lung resections \u2010 single\u2010site experience","volume":"101","author":"Hanuliak J.","year":"2022","journal-title":"Rozhledy v Chirurgii"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2021.11829"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12061742"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-020-01299-8"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.690875"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci8050074"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.4322\/acr.2021.271"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-021-01544-8"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2022.05.005"},{"key":"e_1_2_7_21_1","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.02472-20","article-title":"The brief case: Capnocytophaga sputigena Bacteremia in a 94\u2010year\u2010old male with type 2 diabetes mellitus, pancytopenia, and bronchopneumonia","volume":"59","author":"Liu B. 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