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Acetylcholinesterase (AChE), and human carbonic anhydrase (hCA) inhibitory qualifications of these compounds were determined. The reported compounds (<jats:bold>2a<\/jats:bold>\u2010<jats:bold>y<\/jats:bold>) were determined to be effective inhibitors of the hCA I, hCA II and AChE enzymes with K<jats:italic>i<\/jats:italic> values in the range of 1.130\u2009\u00b1\u20090.15\u20135.440\u2009\u00b1\u20090.93\u2009\u03bcM for hCA I, 0.894\u2009\u00b1\u20090.05\u20136.647\u2009\u00b1\u20091.35\u2009\u03bcM for hCA II, and 0.196\u2009\u00b1\u20090.03\u20134.222\u2009\u00b1\u20091.04\u2009\u03bcM for AChE. In silico studies were also performed to illuminate the binding interactions.<\/jats:p>","DOI":"10.1111\/cbdd.14482","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T02:11:00Z","timestamp":1708481460000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Design, synthesis, and evaluation of novel bistrifluoromethyl\u2010based hydrazones as dual inhibitors of acetylcholinesterase and carbonic anhydrase enzymes for Alzheimer's disease"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5445-0600","authenticated-orcid":false,"given":"Efe Do\u011fukan","family":"Dincel","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, Department of Pharmaceutical Chemistry Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4890-3124","authenticated-orcid":false,"given":"Faika","family":"Ba\u015fo\u011flu\u2010\u00dcnal","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Pharmaceutical Chemistry European University of Lefke  Mersin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebru Didem","family":"Kuran","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Pharmaceutical Chemistry Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00fclay","family":"Kayra","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Pharmaceutical Chemistry Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurcan","family":"Ayd\u0131n","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Pharmaceutical Chemistry Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esmanur","family":"Kanber","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Pharmaceutical Chemistry Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130lhami","family":"G\u00fcl\u00e7in","sequence":"additional","affiliation":[{"name":"Faculty of Science, Department of Chemistry Atat\u00fcrk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuray","family":"Ulusoy\u2010G\u00fczeldemirci","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Pharmaceutical Chemistry Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.13896"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2021.131398"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2018.03.001"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.5455\/medscience.2019.08.9188"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2022.132673"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u20102952(61)90145\u20109"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23030634"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2016.1243536"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2016.1254207"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.35333\/jrp.2020.156"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201078782\u20105"},{"key":"e_1_2_8_13_1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/0-387-23226-5_15","volume-title":"Alzheimer's Disease: Cellular and Molecular Aspects of Amyloid \u03b2","author":"Inestrosa N. 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