{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:39:55Z","timestamp":1791567595378,"version":"4.3.4"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T00:00:00Z","timestamp":1713225600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    An early exploration of the benzothiazole class against two kinetoplastid parasites,\n                    <jats:italic>Leishmania infantum<\/jats:italic>\n                    and\n                    <jats:italic>Trypanosoma cruzi<\/jats:italic>\n                    , has been performed after the identification of a benzothiazole derivative as a suitable antileishmanial initial hit. The first series of derivatives focused on the acyl fragment of its class, evaluating diverse linear and cyclic, alkyl and aromatic substituents, and identified two other potent compounds, the phenyl and cyclohexyl derivatives. Subsequently, new compounds were designed to assess the impact of the presence of diverse substituents on the benzothiazole ring or the replacement of the endocyclic sulfur by other heteroatoms. All compounds showed relatively low cytotoxicity, resulting in decent selectivity indexes for the most active compounds. Ultimately, the in\u00a0vitro ADME properties of these compounds were assessed, revealing a satisfying water solubility, gastrointestinal permeability, despite their low metabolic stability and high lipophilicity. Consequently, compounds\n                    <jats:bold>5<\/jats:bold>\n                    and\n                    <jats:bold>6<\/jats:bold>\n                    were identified as promising hits for further hit\u2010to\u2010lead exploration within this benzothiazole class against\n                    <jats:italic>L. infantum<\/jats:italic>\n                    , thus providing promising starting points for the development of antileishmanial candidates.\n                  <\/jats:p>","DOI":"10.1111\/cbdd.14525","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T22:14:58Z","timestamp":1713305698000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Evaluation and discovery of novel benzothiazole derivatives as promising hits against\n                    <i>Leishmania infantum<\/i>"],"prefix":"10.1111","volume":"103","author":[{"given":"Thibault Joseph William Jacques Dit","family":"Lapierre","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de S\u00edntese de Candidatos a F\u00e1rmacos Instituto de Qu\u00edmica, Universidade Federal de Uberl\u00e2ndia (UFU)  Uberl\u00e2ndia Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo Nascimento","family":"Farago","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de S\u00edntese de Candidatos a F\u00e1rmacos Instituto de Qu\u00edmica, Universidade Federal de Uberl\u00e2ndia (UFU)  Uberl\u00e2ndia Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariza Gabriela Faleiro","family":"de Moura\u00a0Lodi\u00a0Cruz","sequence":"additional","affiliation":[{"name":"Grupo de Gen\u00f4mica Funcional de Parasitos Instituto Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz (FIOCRUZ Minas)  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"de Melo\u00a0Resende","sequence":"additional","affiliation":[{"name":"Grupo de Gen\u00f4mica Funcional de Parasitos Instituto Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz (FIOCRUZ Minas)  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriane Cristina Rosa","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de S\u00edntese de Candidatos a F\u00e1rmacos Instituto de Qu\u00edmica, Universidade Federal de Uberl\u00e2ndia (UFU)  Uberl\u00e2ndia Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda Rosa Macedo","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de S\u00edntese de Candidatos a F\u00e1rmacos Instituto de Qu\u00edmica, Universidade Federal de Uberl\u00e2ndia (UFU)  Uberl\u00e2ndia Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"de Oliveira\u00a0Souza","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biomol\u00e9culas e Espectrometria de Massas (LaBioMass) Universidade Estadual de Maring\u00e1 (UEM)  Maring\u00e1 Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Michelan\u2010Duarte","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Qu\u00edmica Medicinal e Computacional (LQMC) Instituto de F\u00edsica de S\u00e3o Carlos (IFSC), Universidade de S\u00e3o Paulo (USP)  S\u00e3o Carlos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael C.","family":"Chelucci","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Qu\u00edmica Medicinal e Computacional (LQMC) Instituto de F\u00edsica de S\u00e3o Carlos (IFSC), Universidade de S\u00e3o Paulo (USP)  S\u00e3o Carlos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano D.","family":"Andricopulo","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Qu\u00edmica Medicinal e Computacional (LQMC) Instituto de F\u00edsica de S\u00e3o Carlos (IFSC), Universidade de S\u00e3o Paulo (USP)  S\u00e3o Carlos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo L. 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