{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T18:58:00Z","timestamp":1780513080715,"version":"3.54.1"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T00:00:00Z","timestamp":1715904000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["CRG\/2022\/004763"],"award-info":[{"award-number":["CRG\/2022\/004763"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tyrosinase is a copper\u2010containing enzyme involved in the biosynthesis of melanin pigment. While the excess production of melanin causes hyperpigmentation of human skin, hypopigmentation results in medical conditions like vitiligo. Tyrosinase inhibitors could be used as efficient skin whitening agents and tyrosinase agonists could be used for enhanced melanin synthesis and skin protection from UV exposure. Among a wide range of tyrosinase\u2010regulating compounds, natural and synthetic derivatives of furochromenones, such as 8\u2010methoxypsoralen (8\u2010MOP), are known to both activate and inhibit tyrosinase. We recently reported a synthetic approach to generate a variety of dihydrofuro[3,2\u2010c]chromenones and furo[3,2\u2010c]chromenones in a metal\u2010free condition. In the present study, we investigated these compounds for their potential as antagonists or agonists of tyrosinase. Using fungal tyrosinase\u2010based in\u00a0vitro biochemical assay, we obtained one compound (<jats:bold>3k<\/jats:bold>) which could inhibit tyrosinase activity, and the other compound (<jats:bold>4f<\/jats:bold>) that stimulated tyrosinase activity. The kinetic studies revealed that compound <jats:bold>3k<\/jats:bold> caused \u2018mixed\u2019 type tyrosinase inhibition and <jats:bold>4f<\/jats:bold> stimulated the catalytic efficiency. Studying the mechanisms of these compounds may provide a basis for the development of new effective tyrosinase inhibitors or activators.<\/jats:p>","DOI":"10.1111\/cbdd.14539","type":"journal-article","created":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T01:38:52Z","timestamp":1715996332000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of a panel of furochromenones as the activator and inhibitor of tyrosinase"],"prefix":"10.1111","volume":"103","author":[{"given":"Gayathri","family":"Seenivasan","sequence":"first","affiliation":[{"name":"Department of Biotechnology Indian Institute of Technology Hyderabad (IITH)  Sanga Reddy Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarwat Asma Ziya","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Hyderabad (IITH)  Sanga Reddy Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil Kumar","family":"Tuti","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Indian Institute of Technology Hyderabad (IITH)  Sanga Reddy Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Unnikrishnan P.","family":"Shaji","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Indian Institute of Technology Hyderabad (IITH)  Sanga Reddy Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susmita","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Indian Institute of Technology Hyderabad (IITH)  Sanga Reddy Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faiz Ahmed","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Hyderabad (IITH)  Sanga Reddy Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Anindya","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Indian Institute of Technology Hyderabad (IITH)  Sanga Reddy Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21134618"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm901137j"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.47583\/ijpsrr.2021.v67i02.011"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014\u20105793(96)00109\u20103"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf800109a"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.06.013"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi200395t"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20101912\u20103884"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19030746"},{"key":"e_1_2_8_11_1","first-page":"165","article-title":"Safety and therapeutic effectiveness of 8\u2010methoxypsoralen, 4,5\u2032,8\u2010trimethylpsoralen, and psoralen in vitiligo","volume":"66","author":"Pathak M. A.","year":"1984","journal-title":"National Cancer Institute Monograph"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.27.1144"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2016.1256882"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2018.1545767"}],"container-title":["Chemical Biology &amp; Drug Design"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cbdd.14539","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T12:28:20Z","timestamp":1716812900000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cbdd.14539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/cbdd.14539"],"URL":"https:\/\/doi.org\/10.1111\/cbdd.14539","archive":["Portico"],"relation":{},"ISSN":["1747-0277","1747-0285"],"issn-type":[{"value":"1747-0277","type":"print"},{"value":"1747-0285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"2024-01-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14539"}}