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Pharmacological methods of intervening the reproduction of various less popular, but not less important viruses are not available, as well as the spectrum of antiviral activity for most known compounds. In the framework of chemical biology paradigm, characterization of antiviral activity spectrum of new compounds allows to extend the antiviral chemical space and provides new important structure\u2013activity relationships for data\u2010driven drug discovery. Here we present a primary assessment of antiviral activity of spiro\u2010annulated derivatives of seven\u2010membered heterocycles, oxepane and azepane, in phenotypic assays against viruses with different genomes, virion structures, and genome realization schemes: orthoflavivirus (tick\u2010borne encephalitis virus, TBEV), enteroviruses (poliovirus, enterovirus A71, echovirus 30), adenovirus (human adenovirus C5), hantavirus (Puumala virus). Hit compounds inhibited reproduction of adenovirus C5, the only DNA virus in the studied set, in the yield reduction assay, and did not inhibit reproduction of RNA viruses.<\/jats:p>","DOI":"10.1111\/cbdd.14553","type":"journal-article","created":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T02:29:52Z","timestamp":1716604192000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Phenotypic assessment of antiviral activity for <scp>spiro\u2010annulated<\/scp> oxepanes and azepenes"],"prefix":"10.1111","volume":"103","author":[{"given":"Dmitry I.","family":"Osolodkin","sequence":"first","affiliation":[{"name":"FSASI \u201cChumakov FSC R&amp;D IBP RAS\u201d (Institute of Poliomyelitis)  Moscow Russia"},{"name":"Sechenov First Moscow State Medical University  Moscow Russia"},{"name":"Department of Chemistry Lomonosov Moscow State University  Moscow 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Poliomyelitis)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna N.","family":"Vetrova","sequence":"additional","affiliation":[{"name":"FSASI \u201cChumakov FSC R&amp;D IBP RAS\u201d (Institute of Poliomyelitis)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darya O.","family":"Yatsenko","sequence":"additional","affiliation":[{"name":"FSASI \u201cChumakov FSC R&amp;D IBP RAS\u201d (Institute of Poliomyelitis)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander S.","family":"Goryashchenko","sequence":"additional","affiliation":[{"name":"FSASI \u201cChumakov FSC R&amp;D IBP RAS\u201d (Institute of Poliomyelitis)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir N.","family":"Ivanov","sequence":"additional","affiliation":[{"name":"Department of Chemistry Lomonosov Moscow State University  Moscow 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