{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:30:20Z","timestamp":1791599420612,"version":"4.3.4"},"reference-count":105,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,8,18]],"date-time":"2024-08-18T00:00:00Z","timestamp":1723939200000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009085","name":"Jain University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009085","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>To increase the success rate of drug discovery, one practical strategy is to begin molecular hybridisation. The presence of two or more pharmacophores in a single unit leads to a pharmacological potency greater than the sum of each individual moiety's potency. Heterocyclic compounds are very widely distributed in nature and are essential for life activities. Benzimidazole and oxadiazole are privileged structures in medicinal chemistry and are widely used in drug discovery and development due to their vast biological properties. The drug\u2010like properties (like pharmacokinetics and pharmacodynamics) of the individual scaffolds can be improved by benzimidazole\u2013oxadiazole chimeric molecules via a molecular hybridisation approach. Benzimidazole and oxadiazole cores can either be fused or incorporated using either functional groups\/bonds. Over the last few decades, drug discovery scientists have predicted that these moieties could be interconnected to yield a novel or modified hybrid compound. Benzimidazole and oxadiazole hybrids were identified as the most potent anticancer, antimicrobial, anti\u2010inflammatory, antioxidant, anticonvulsant, antidepressant, antihypertensive and antitubercular agents. In this context, the present review describes the biological properties of benzimidazole\u2013oxadiazole (1,3,4 and 1,2,4) hybrids, their possible structure\u2013activity relationship and the mechanism of action studies presented. This review article is intended to stimulate fresh ideas in the search for rational designs of more active and less toxic benzimidazole\u2013oxadiazole hybrid prospective therapeutic candidates, as well as more effective diagnostic agents and pathologic probes.<\/jats:p>","DOI":"10.1111\/cbdd.14609","type":"journal-article","created":{"date-parts":[[2024,8,18]],"date-time":"2024-08-18T21:45:20Z","timestamp":1724017520000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Benzimidazole\u2013Oxadiazole Hybrids\u2014Development in Medicinal Chemistry: An Overview"],"prefix":"10.1111","volume":"104","author":[{"given":"Raveendra\u00a0Madhukar","family":"Bhat","sequence":"first","affiliation":[{"name":"Centre for Nano and Material Sciences Jain (Deemed\u2010To\u2010Be University)  Bangalore Karnataka India"},{"name":"Aurigene Pharmaceutical Services  Bangalore Karnataka 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