{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:07:34Z","timestamp":1791925654992,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004625","name":"Universiti Teknologi MARA","doi-asserted-by":"publisher","award":["600\u2010RMC\/GIP 5\/3 (100\/2022)"],"award-info":[{"award-number":["600\u2010RMC\/GIP 5\/3 (100\/2022)"]}],"id":[{"id":"10.13039\/501100004625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Diabetes Mellitus (DM) is linked to various factors causing cardiovascular diseases, with uncontrolled postprandial hyperglycemia being a direct contributor. <jats:italic>\u03b1<\/jats:italic>\u2010Glucosidase inhibitors (AGIs) aid in reducing postprandial hyperglycemia, potentially mitigating cardiovascular risks. In order to synthesize novel chemical scaffolds with possible <jats:italic>\u03b1\u2010<\/jats:italic>glucosidase inhibition activity, a series of novel soritin sulfonamide derivatives were synthesized. The soritin hydrazide was treated with various aryl sulfonyl chlorides to obtain targeted compounds (<jats:bold>1\u201316<\/jats:bold>). Findings suggested that all compounds have better <jats:italic>\u03b1\u2010<\/jats:italic>glucosidase inhibition compared to standard drugs, acarbose (2187.00\u2009\u00b1\u20091.25\u2009\u03bcM) and 1\u2010deoxynojirimycin (334.90\u2009\u00b1\u20091.10\u2009\u03bcM), with IC<jats:sub>50<\/jats:sub> values ranging from 3.81\u2009\u00b1\u20091.67\u2009\u03bcM to 265.40\u2009\u00b1\u20091.58\u2009\u03bcM. The most potent analog was Compound <jats:bold>13<\/jats:bold>, a trichloro phenyl substituted compound, with IC<jats:sub>50<\/jats:sub> value of 3.81\u2009\u00b1\u20091.67\u2009\u03bcM. Structure\u2013activity relationship (SAR) showed that introducing an additional chlorine group into the parent nucleus increases the potency. The docking studies validated that Compound <jats:bold>13<\/jats:bold> established hydrogen bonds with the active site residues Asp214, Glu276, and Asp349, while being further stabilized by hydrophobic interactions, providing an explanation for its high potency.<\/jats:p>","DOI":"10.1111\/cbdd.14614","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T08:55:01Z","timestamp":1727427301000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Synthesis of Novel Soritin Sulfonamide Derivatives as Potential <i>\u03b1<\/i>\u2010Glucosidase Inhibitor and Their Molecular Docking Studies"],"prefix":"10.1111","volume":"104","author":[{"given":"Nurul\u00a0Alam","family":"Inayatsyah","sequence":"first","affiliation":[{"name":"Atta\u2010Ur\u2010Rahman Institute for Natural Product Discovery Universiti Teknologi MARA (UiTM)  Bandar Puncak Alam Selangor Malaysia"},{"name":"Faculty of Applied Science UiTM  Shah Alam Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad\u00a0Jemain\u00a0Mohamad","family":"Ridhwan","sequence":"additional","affiliation":[{"name":"Atta\u2010Ur\u2010Rahman Institute for Natural Product Discovery Universiti Teknologi MARA (UiTM)  Bandar Puncak Alam Selangor Malaysia"},{"name":"Faculty of Applied Science UiTM  Shah Alam Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alim\u00a0Alsukor","family":"Aznirulhisham","sequence":"additional","affiliation":[{"name":"Atta\u2010Ur\u2010Rahman Institute for Natural Product Discovery Universiti Teknologi MARA (UiTM)  Bandar Puncak Alam Selangor Malaysia"},{"name":"Faculty of Applied Science UiTM  Shah Alam Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurulfazlina\u00a0Edayah","family":"Rasol","sequence":"additional","affiliation":[{"name":"Atta\u2010Ur\u2010Rahman Institute for Natural Product Discovery Universiti Teknologi MARA (UiTM)  Bandar Puncak Alam Selangor Malaysia"},{"name":"Faculty of Applied Science UiTM  Shah Alam Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noraini","family":"Kasim","sequence":"additional","affiliation":[{"name":"Atta\u2010Ur\u2010Rahman Institute for Natural Product Discovery Universiti Teknologi MARA (UiTM)  Bandar Puncak Alam Selangor Malaysia"},{"name":"Faculty of Applied Science UiTM  Shah Alam Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7802-7359","authenticated-orcid":false,"given":"Syahrul","family":"Imran","sequence":"additional","affiliation":[{"name":"Atta\u2010Ur\u2010Rahman Institute for Natural Product Discovery Universiti Teknologi MARA (UiTM)  Bandar Puncak Alam Selangor Malaysia"},{"name":"Faculty of Applied Science UiTM  Shah Alam Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,20]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Alpha Glucosidase Inhibitors","author":"Akmal M.","year":"2020"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2019.06.041"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3210557"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253\u2010014\u20105587\u20109"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8100421"},{"key":"e_1_2_7_7_1","volume-title":"Oral and Injectable (Non\u2010Insulin) Pharmacological Agents for Type 2 Diabetes","author":"Feingold K. 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