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Thirty Sprague\u2013Dawley (SD) rats were randomly divided into five groups: the Control group, the CCL4 group, the CCL4\u2009+\u2009Ech 25\u2009mg\/kg group, the CCL4\u2009+\u2009Ech 50\u2009mg\/kg group, and the CCL4\u2009+\u2009Ech 100\u2009mg\/kg group. The rats were injected intraperitoneally with CCL4 solution twice a week to induce chronic liver injury, and Ech intervention lasted for 4\u2009weeks. After the intervention, the liver and blood samples from rats were collected for subsequent analysis. Ech effectively reduced the levels of serum liver injury markers (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, alkaline phosphatase, and total bilirubin), attenuated the hepatocyte degeneration and necrosis, improved the severity of liver fibrosis, and inhibited the local inflammatory response of the liver in a dose\u2010dependent manner. Ech effectively mitigated CCL4\u2010induced chronic liver injury in rats by downregulating the NF\u2010\u03baB\/NLRP3 inflammasome pathway.<\/jats:p>","DOI":"10.1111\/cbdd.14616","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T03:23:31Z","timestamp":1725852211000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Echinacoside Alleviates Carbon Tetrachloride\u2010Induced Chronic Liver Injury by Modulating the <scp>NF<\/scp>\u2010<scp>\u03baB<\/scp>\/<scp>NLRP3<\/scp> Inflammasome Pathway"],"prefix":"10.1111","volume":"104","author":[{"given":"Ye\u2010jun","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Changzhou Third People's Hospital  Changzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hepatology with Integrated Traditional Chinese and Western Medicine Changzhou Third People's Hospital  Changzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1751\u20102980.12918"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/0001\u20103765201920181235"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24282"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001259"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI93562"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132629"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.630536"},{"key":"e_1_2_12_9_1","first-page":"495","article-title":"Hepatoprotective Activity of Cinnamon Ethanolic Extract Against CCI4\u2010Induced Liver Injury in Rats","volume":"11","author":"Eidi A.","year":"2012","journal-title":"EXCLI Journal"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010immunol\u2010081022\u2010021207"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41395\u2010018\u20100160\u20102"},{"key":"e_1_2_12_12_1","first-page":"53","article-title":"Drug\u2010Induced Hepatotoxicity in Humans","volume":"11","author":"Halegoua\u2010De Marzio D.","year":"2008","journal-title":"Current Opinion in Drug Discovery & Development"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010pathol\u2010011110\u2010130246"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/17562848231163410"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18051018"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200311133492021"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/msystems.01127\u201022"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102008\u20101073114"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.05.072"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.806249"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(20)30006\u20106"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2019.02.012"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1124\/pharmrev.122.000629"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.c19\u201000008"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242316556"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15046990"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2016.3"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033\u2010023\u201008666\u20100"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.32725\/jab.2021.011"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.3629"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064\u2010019\u201002782\u20109"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033\u2010021\u201006674\u20106"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm13030386"}],"container-title":["Chemical Biology &amp; 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