{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T17:48:59Z","timestamp":1778608139511,"version":"3.51.4"},"reference-count":115,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Parkinson's disease (PD) stands as the second most common neurological disorder after Alzheimer's disease, primarily affecting the elderly population and significantly compromising their quality of life. The precise etiology of PD remains elusive, but recent research has shed light on potential factors, including the formation of \u03b1\u2010synuclein aggregates, oxidative stress, neurotransmitter imbalances, and dopaminergic neurodegeneration in the substantia nigra pars compacta (SNpc) region of the brain, culminating in motor symptoms such as bradykinesia, akinesia, tremors, and rigidity. Monoamine oxidase (MAO) is an essential enzyme, comprising two isoforms, MAO\u2010A and MAO\u2010B, responsible for the oxidation of monoamines such as dopamine. Increased MAO\u2010B activity is responsible for decreased dopamine levels in the SNpc region of mid brain which is remarkably associated with the pathogenesis of PD\u2010like manifestations. Inhibitors of MAO\u2010B enhance striatal neuronal responses to dopamine, making them valuable in treating PD, which involves dopamine deficiency. Clinically approved MAO\u2010B inhibitors such as selegiline, L\u2010deprenyl, pargyline, and rasagiline are employed in the management of neurodegenerative conditions associated with PD. Current therapeutic interventions including MAO\u2010B inhibitors for PD predominantly aim to alleviate these motor symptoms but often come with a host of side effects that can be particularly challenging for the patients. While effective, they have limitations, prompting a search for alternative treatments, there is a growing interest in exploring natural products notably flavonoids as potential sources of novel MAO\u2010B inhibitors. In line with that, the present review focuses on natural flavonoids of plant origin that hold promise as potential candidates for the development of novel MAO\u2010B inhibitors. The discussion encompasses both in\u00a0vitro and in\u00a0vivo studies, shedding light on their potential therapeutic applications. Furthermore, this review underscores the significance of exploring natural products as valuable reservoirs of MAO\u2010B inhibitors, offering new avenues for drug development and addressing the pressing need for improved treatments in PD\u2010like pathological conditions. The authors of this review majorly explore the neuroprotective potential of natural flavonoids exhibiting notable MAO\u2010B inhibitory activity and additionally multi\u2010targeted approaches in the treatment of PD with clinical evidence and challenges faced in current therapeutic approaches.<\/jats:p>","DOI":"10.1111\/cbdd.14619","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T04:45:08Z","timestamp":1725338708000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Dietary Natural Flavonoids: Intervention for <scp>MAO<\/scp>\u2010B Against Parkinson's Disease"],"prefix":"10.1111","volume":"104","author":[{"given":"Ashini","family":"Singh","sequence":"first","affiliation":[{"name":"Division of Pharmacology, Institute of Pharmaceutical Research GLA University  Mathura India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suman","family":"Sinha","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Chemistry, Institute of Pharmaceutical Research GLA University  Mathura India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5625-5067","authenticated-orcid":false,"given":"Niraj\u00a0Kumar","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, Institute of Pharmaceutical Research GLA University  Mathura India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1386207326666230510141008"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.04.026"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673\u20105374.375299"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X16666180830100754"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.5620\/eaht.e2020001"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2019.104612"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.22360"},{"key":"e_1_2_9_9_1","unstructured":"Bagheri M.2012.\u201cNeuroprotective Effect of Genistein: Studies in Rat Models of Parkinson's and Alzheimer's Disease.\u201d"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2008.05.002"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2008.06.004"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007758"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2010.10.027"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11030\u2010013\u20109490\u20106"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2018.1427735"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010017\u20108523\u2010y"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.4162\/nrp.2013.7.5.393"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2017.1293285"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24040810"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270005277935"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035\u2010016\u20100059\u2010z"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20205208"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2005.09.006"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0505975102"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7043213"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.01.018"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24030418"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD\u2010130230"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2017.07.033"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11020247"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10101604"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3574012"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871524919666190619090852"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6241017"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2016.04.025"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26050"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.23619"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.14210"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.14415"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.6b01707"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064\u2010012\u20100751\u2010z"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12017\u2010016\u20108398\u20106"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD\u2010160965"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2019.03.001"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1515\/tnsci\u20102018\u20100022"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2019.11.079"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880200490893492"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B1100137"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23040814"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2016.01.011"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules16021471"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.63.7_suppl_2.s13"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.66.10_suppl_4.s24"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3639"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu4101399"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2017.4078"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/cn5002914"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(14)61393\u20103"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2013.1571"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2017.10.048"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531\u2010017\u20100015\u20103"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10050642"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1385\/MN:30:1:077"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/162750"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007020170018"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2017.12.032"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24071435"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf010622j"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4785089"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2007.10.005"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20123056"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001616"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/79.5.727"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571\u2010021\u201001078\u20103"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010211\u201033328\u20100_7"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311\u2010021\u201001097\u20104"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.116797"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394\u2010003\u20100397\u20103"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/403503"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612822666151112150612"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2010.01.004"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064\u2010014\u20101259\u20105"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2014.07.012"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8378613"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1021\/np9904509"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2019.10.1271"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.03.057"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.52586\/5007"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2019.07.031"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17060904"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23732"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.11477\/mf.1416200656"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010pathol\u2010011110\u2010130242"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imr.2017.04.003"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1080\/19390211.2018.1472706"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389201024666230801095526"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.2174\/1566524023666230529093314"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2021.10.003"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2015.1086748"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2017.0204"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13691"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702\u2010019\u201002082\u20100"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X15666170510143821"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD\u2010212976"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100037\u20101601888"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu5093367"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/4807179"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25225243"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.10"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep16127"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M202844200"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702\u2010015\u20101398\u20100"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00430"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1423052"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.09.068"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2006.12.013"}],"container-title":["Chemical Biology &amp; Drug Design"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cbdd.14619","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T08:55:40Z","timestamp":1727427340000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cbdd.14619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":115,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/cbdd.14619"],"URL":"https:\/\/doi.org\/10.1111\/cbdd.14619","archive":["Portico"],"relation":{},"ISSN":["1747-0277","1747-0285"],"issn-type":[{"value":"1747-0277","type":"print"},{"value":"1747-0285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"2024-02-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14619"}}