{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T14:15:18Z","timestamp":1791728118716,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T00:00:00Z","timestamp":1726531200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20212BAB206058"],"award-info":[{"award-number":["20212BAB206058"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Arctigenin (Ar) is a promising therapeutic candidate for postmenopausal osteoporosis (PMOP). This study explores its mechanism by examining its effects on adipogenesis and osteogenesis in ovariectomized (OVX) rats. In\u00a0vitro, Ar effectively suppressed the adipogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) from OVX rats, reducing lipid droplet formation and downregulating proteins associated with lipid synthesis. In\u00a0vivo, Ar treatment significantly reduced bone loss, inhibited adipocyte development, improved lipid metabolism, and promoted bone formation in OVX rats. Mechanistically, Ar inhibited the phosphorylation of Mitogen\u2010Activated Protein Kinase 1 (MEK1), downregulated Peroxisome Proliferator\u2010Activated Receptor gamma (PPAR\u03b3), promoted the accumulation of \u03b2\u2010catenin in the nucleus, and prevented the direct binding of PPAR\u03b3 to \u03b2\u2010catenin in BMSCs. This regulation of the PPAR\u03b3\/Wnt signaling axis underlies its dual role in inhibiting adipogenesis and promoting osteogenesis. Notably, co\u2010treatment with rosiglitazone (RGZ) reversed the effects of Ar on adipogenesis and osteogenesis without affecting MEK1 inhibition. These findings offer valuable insights into arctigenin's potential as a therapeutic strategy for PMOP by modulating MEK1 signaling and regulating the PPAR\u03b3\/Wnt axis.<\/jats:p>","DOI":"10.1111\/cbdd.14625","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T02:19:07Z","timestamp":1726625947000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Arctigenin Modulates Adipogenic\u2010Osteogenic Balance in the Bone Marrow Microenvironment of Ovariectomized Rats via the <scp>MEK1<\/scp>\/<scp>PPAR\u03b3<\/scp>\/Wnt\/\u03b2\u2010Catenin Pathway"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8411-6670","authenticated-orcid":false,"given":"Hongbo","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang Jiangxi China"},{"name":"Department of Orthopedic Surgery Jiangxi Provincial People's Hospital  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingen","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Jiangxi Provincial People's Hospital  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Jiangxi Provincial People's Hospital  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianying","family":"He","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Jiangxi Provincial People's Hospital  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingping","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Jiangxi Provincial People's Hospital  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Jiangxi Provincial People's Hospital  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Jiangxi Provincial People's Hospital  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Jiangxi Provincial People's Hospital  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Jiangxi Provincial People's Hospital  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guicai","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2021.03.009"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2018.04.011"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2018.04.014"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.23736\/S2724\u2010606X.21.04896\u2010X"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.24.1_supplement.726.2"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.305116"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v11.i12.1084"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2004.06.011"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.05.012"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202303494"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.09.015"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c03781"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.627429"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2018.32"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2020.4606"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25509"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198\u2010010\u20101491\u2010z"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2021.155488"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.624112"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12071950"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142201"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2012.02.026"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.13659"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2015.1206"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574888X12666171012141908"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12986\u2010017\u20100234\u2010y"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.616813"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00441\u201006"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5598980"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12814"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2018.05.019"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21010349"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/c9nr07171g"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(10)62349\u20105"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010biochem\u2010081720\u2010114505"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10\u20101672"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.174419"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.28602"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv\u201014\u20104\u2010424"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00745"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21787"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S444347"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15261"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085878"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574888x10666150519093429"}],"container-title":["Chemical Biology &amp; Drug Design"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cbdd.14625","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T08:56:29Z","timestamp":1727427389000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cbdd.14625"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/cbdd.14625"],"URL":"https:\/\/doi.org\/10.1111\/cbdd.14625","archive":["Portico"],"relation":{},"ISSN":["1747-0277","1747-0285"],"issn-type":[{"value":"1747-0277","type":"print"},{"value":"1747-0285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"2024-04-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14625"}}