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Then, assessments were made on the pathological variation in the heart of mouse, on the cardiac functions, as well as on the expressions of cardiac hypertrophy markers (\u03b2\u2010MHC, ANP, and BNP), inflammatory factors (TNF\u2010\u03b1, COX2, IL\u20106, ICAM\u20101, and VCAM\u20101), myocardial cell pyroptosis markers (NLRP3, ASC, c\u2010caspase\u20101, and GSDMD\u2010N), and Hippo pathway proteins (p\u2010YAP, YAP, LATS1, and p\u2010LATS1) by HE staining, echocardiography scanning, and western blot tests separately. The expressions of such inflammatory factors as in myocardial tissue were acquired by ELISA. After inducing the phenotype of H9c2 cell hypertrophy by noradrenaline, we used CCK\u20108 kits to know about the activity of H9c2 cells treated with Apelin\u201013, and performed \u0251\u2010actinin staining to measure the changes in volumes of such cells. As unraveled through this work, Apelin\u201013 refrained the activation of the Hippo pathway, which in turn attenuated the hypertrophy, inflammation, and pyroptosis of myocardial tissue and H9c2 cells. Hence, Apelin\u201013 can be considered as a target for hypertension treatment.<\/jats:p>","DOI":"10.1111\/cbdd.14628","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T02:23:16Z","timestamp":1728872596000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Apelin\u201013's Actions in Controlling Hypertension\u2010Related Cardiac Hypertrophy and the Expressions of Inflammatory Cytokines"],"prefix":"10.1111","volume":"104","author":[{"given":"Xiaoliang","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Disease IV The Fifth Affiliated Hospital of Sun Yat\u2010sen University  Zhuhai Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyun","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Disease I The Fifth Affiliated Hospital of Sun Yat\u2010sen University  Zhuhai 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