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Cytotoxic and antimigratory potential was addressed by using a colorectal cancer cell line as a model system. Although possessing no cytotoxic effects, two compounds have shown strong antimigratory potential in low doses, with no effect on healthy MRC\u20105 cells. Evaluation of their antimicrobial activities suggested prominent antimicrobial activity, where Compound <jats:bold>4<\/jats:bold> outperformed streptomycin against <jats:italic>Escherichia coli<\/jats:italic> and <jats:italic>Proteus mirabilis<\/jats:italic>. Hormone\u2010dependent types of cancer, such as prostate, ovary, and breast, are highly dependent on human sex hormone\u2013binding globulin (SHBG) blood levels. A molecular docking study has shown that <jats:bold>1<\/jats:bold> has high affinity to bind and therefore compete with natural steroids for the SHBG steroid\u2010binding site. DNA\u2010binding study have shown that <jats:bold>4<\/jats:bold> interacts with CT\u2010DNA in a groove\u2010binding mode. <jats:italic>In silico<\/jats:italic> ADME\/T study revealed that all compounds have suitable physicochemical properties for oral bioavailability and druglikeness, while toxicity tests for <jats:bold>1<\/jats:bold>, <jats:bold>4,<\/jats:bold> and <jats:bold>6<\/jats:bold> suggested potential for mutagenicity (<jats:bold>4, 6<\/jats:bold>), hepatotoxicity (<jats:bold>6<\/jats:bold>), and skin sensation (<jats:bold>1<\/jats:bold>).<\/jats:p>","DOI":"10.1111\/cbdd.70001","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T04:25:58Z","timestamp":1729052758000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Tyramine Derivatives as Versatile Pharmacophores With Potent Biological Properties: Sex Hormone\u2013Binding Globulin Inhibition, Colon Cancer Antimigration, 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