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Tectorigenin has been demonstrated to exert anti\u2010inflammatory effect. Here, we aimed to investigate the effects of tectorigenin on DBV\u2010induced cytokine storm. Effects of tectorigenin on cytokines in DBV\u2010infected THP\u20101 cells and plasma samples of Type I interferon receptor (IFNAR)\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice infected with DBV were detected. The changes in body weight and survival time of mice were recorded. The liver, spleen, kidney, and lymph node tissues were collected for hematoxylin\u2013eosin staining. We demonstrated that tectorigenin reduced the expression levels of inflammatory cytokines in both DBV\u2010infected THP\u20101 cells and plasma samples of IFNAR\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice infected with DBV. Tectorigenin attenuated DBV\u2010induced histopathological changes in mice. Mechanistically, tectorigenin attenuated DBV\u2010induced phosphorylation of inhibitor of kappa\u2010B kinase alpha\/beta (IKK\u03b1\/\u03b2) of the nuclear factor\u2010\u03baB (NF\u2010\u03baB) signaling pathway, extracellular signal\u2013regulated kinase (ERK) of the mitogen\u2010activated protein kinase (MAPK) signaling pathway and might function by downregulation of Toll\u2010like receptor. The result of this study suggested that tectorigenin exerted anti\u2010inflammatory effects in\u00a0vivo and in\u00a0vitro and could serve as a novel potential therapeutic strategy for SFTS.\n                  <\/jats:p>","DOI":"10.1111\/cbdd.70005","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T21:34:08Z","timestamp":1734125648000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Tectorigenin Reduces\n                    <i>Dabie bandavirus<\/i>\n                    \u2010Induced Cytokine Storm by Regulating Toll\u2010Like Receptor 7\/Extracellular Signal\u2013Regulated Kinase Pathway"],"prefix":"10.1111","volume":"104","author":[{"given":"Qian","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Infectious Disease The First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu China"},{"name":"Department of Infectious Disease Shanghai 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