{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T09:04:51Z","timestamp":1791882291046,"version":"4.3.4"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007613","name":"Ankara Universitesi","doi-asserted-by":"publisher","award":["20B0237002"],"award-info":[{"award-number":["20B0237002"]}],"id":[{"id":"10.13039\/100007613","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\"><jats:italic>Heracleum sphondylium<\/jats:italic><\/jats:styled-content> subsp. <jats:italic>cyclocarpum<\/jats:italic> (K. Koch) P.H. Davis from <jats:italic>Heracleum<\/jats:italic> L. genus, which is one of the widest genera of the Apiaceae family and known as \u201cHogweed or Tav\u015fanc\u0131lotu\u201d. This genus has a variety of traditional uses, including treating gastrointestinal, cardiovascular, gynecological, and cognitive disorders, skin problems, rheumatism, and inflammation. In particular, these plants are commonly used for inflammatory diseases. This research aimed to examine in detail the anti\u2010inflammatory properties of <jats:styled-content style=\"fixed-case\"><jats:italic>Heracleum sphondylium<\/jats:italic><\/jats:styled-content> subsp. <jats:italic>cyclocarpum<\/jats:italic> roots. Bioactivity\u2010guided fractionation was used to isolate the active compounds. Carrageenan\u2010 and prostaglandin E2\u2010induced inflammation models were employed to test the activity. Dichloromethane and methanolic extracts of the plant material were tested for activity and found to be effective in inhibiting inflammation. The subfractions obtained by column chromatography were further evaluated for their activities. The active fractions were used to obtain responsible compounds by using semipreparative HPLC. Five coumarin derivatives were isolated and identified as heraclenol (1), byakangelicin (2), heraclenol\u20103\u2033\u2010<jats:italic>O<\/jats:italic>\u2010<jats:italic>\u03b2<\/jats:italic>\u2010glucoside (3), byakangelicin\u20103\u2033\u2010<jats:italic>O<\/jats:italic>\u2010<jats:italic>\u03b2<\/jats:italic>\u2010glucoside (4), and meranzin hydrate III (5). The isolated compounds were investigated for their anti\u2010inflammatory activities, and heraclenol\u20103\u2033\u2010<jats:italic>O\u2010\u03b2<\/jats:italic>\u2010glucoside was found to inhibit the carrageenan and prostaglandin E2\u2010induced edema significantly compared to the control group and have higher activity than the extracts.<\/jats:p>","DOI":"10.1111\/cbdd.70044","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T05:40:31Z","timestamp":1739511631000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Anti\u2010Inflammatory Compounds From Roots of <i>Heracleum sphondylium<\/i> subsp. <i>cyclocarpum<\/i>"],"prefix":"10.1111","volume":"105","author":[{"given":"Ekin","family":"Kurtul","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Zonguldak B\u00fclent Ecevit University  Zonguldak Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0809-784X","authenticated-orcid":false,"given":"\u00d6zlem Bahad\u0131r","family":"Ac\u0131kara","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Ankara University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00fc\u015fra Karpuz","family":"A\u011f\u00f6ren","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Ba\u015fkent University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra K\u00fcpeli","family":"Akkol","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Gazi University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00564300"},{"key":"e_1_2_9_3_1","first-page":"254","article-title":"Ethnobotanical Investigation of Traditional Medicinal Plants Commercialized in the Markets of Mashhad, Iran","volume":"3","author":"Amiri M. 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