{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T08:55:07Z","timestamp":1771145707998,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Alzheimer's disease is a neurodegenerative chronic disease with a severe social and economic impact in the societies, which still lacks an efficient therapy. Several pathophysiological events (<jats:italic>\u03b2<\/jats:italic>\u2010amyloid [A<jats:italic>\u03b2<\/jats:italic>] deposits, <jats:italic>\u03c4<\/jats:italic>\u2010protein aggregation, loss of cholinergic activity, and oxidative stress) occurs in the progression of the disease. Therefore, the search for efficient multi\u2010targeted agents for the treatment of Alzheimer's disease becomes indispensable. In this paper we evaluated the AChE inhibition by Ellman's method and antioxidant activity by DPPH assay of nine synthetic compounds: two hydroxy\u2010benzene derivatives (<jats:bold>1<\/jats:bold> and <jats:bold>2<\/jats:bold>), three bis\u2010thioureidic derivatives (<jats:bold>3\u20135<\/jats:bold>), two imidazole derivatives (<jats:bold>6<\/jats:bold> and <jats:bold>7<\/jats:bold>), and two phenylacetamide derivatives (<jats:bold>8<\/jats:bold> and <jats:bold>9<\/jats:bold>). The compound <jats:bold>2<\/jats:bold>, (3s,5s,7s)\u2010adamantan\u20101\u2010yl 4\u2010(((<jats:italic>E<\/jats:italic>)\u20102,5\u2010dihydroxybenzylidene)amino)benzoate, exhibited the best antioxidant activity (30.00\u2009\u00b1\u20091.05\u2009\u03bcM\u2009eq Trolox) and compound <jats:bold>4<\/jats:bold> showed the highest AChE inhibition value (IC<jats:sub>50<\/jats:sub> [\u03bcM] 8.40\u2009\u00b1\u20090.32). In the search for a compound showing combined activities (antioxidant and AChE inhibition), the compound <jats:bold>4<\/jats:bold>, octane\u20101,8\u2010diyl\u2010bis\u2010<jats:italic>S<\/jats:italic>\u2010amidinothiourea dihydrobromide, (19.02\u2009\u00b1\u20091.52\u2009\u03bcM\u2009eq Trolox; IC<jats:sub>50<\/jats:sub> [\u03bcM] 8.40\u2009\u00b1\u20090.32) was chosen to carry out a molecular docking study. The results showed that compound <jats:bold>4<\/jats:bold> has the ability to bind the active site of acetylcholinesterase with considerable affinity (estimated binding energies of \u22128.5\u2009kcal\/mol). All data indicate that compound <jats:bold>4<\/jats:bold> has the potential to be further investigated as a possible candidate in the Alzheimer's disease treatment.<\/jats:p>","DOI":"10.1111\/cbdd.70049","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T06:14:30Z","timestamp":1737094470000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Imino and Thioureidic Derivatives as New Tools for Alzheimer's Disease: Preliminary Studies"],"prefix":"10.1111","volume":"105","author":[{"given":"Anna","family":"Caruso","sequence":"first","affiliation":[{"name":"Department of Health Sciences University of Basilicata  Potenza Italy"},{"name":"Department of Pharmacy, Health and Nutritional Sciences University of Calabria  Arcavacata di Rende 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