{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:13:20Z","timestamp":1790856800713,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Cyclin\u2010dependent kinase 9 (CDK9) is considered as an important target in the research of antitumor drugs. Taking the CDK2\/9 inhibitor CYC065 as the positive control and an in\u2010house library compound (<jats:bold>64<\/jats:bold>) as the lead compound, four classes of 22 target compounds with 9H purine as the core structure were designed to establish structure\u2013activity relationships (SAR). In general, SAR of 9H purine CDK9 inhibitors is systematically described in this paper, resulting in the discovery of two compounds (<jats:bold>B2<\/jats:bold> and <jats:bold>B5<\/jats:bold>) with further research value. After conducting selectivity testing against CDK2\/9 kinase, compound <jats:bold>B5<\/jats:bold> demonstrated approximately five\u2010fold greater selectivity towards CDK9\u2010cyclinT1 over CDK2\u2010cyclinE2. This work also provides a reference basis for the subsequent research on CDK9 inhibitors.<\/jats:p>","DOI":"10.1111\/cbdd.70062","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T17:45:56Z","timestamp":1738259156000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Design, Synthesis and Biological Evaluation of Novel <scp>9H<\/scp> Purine Derivatives as Potent <scp>CDK9<\/scp> Inhibitors"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8908-1075","authenticated-orcid":false,"given":"Chunlei","family":"Tang","sequence":"first","affiliation":[{"name":"School of Life Sciences and Health Engineering Jiangnan University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Health Engineering Jiangnan University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huabing","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Health Engineering Jiangnan University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengkai","family":"Cui","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Health Engineering Jiangnan University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weizheng","family":"Fan","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Health Engineering Jiangnan University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Health Engineering Jiangnan University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2024.110940"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01754"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lrr.2012.11.006"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep29090"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00108-3"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(20)31086-8"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-021-03878-8"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2015.04.027"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c01233"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/2767-9764.CRC-23-0219"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2217476120"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2020-140865"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13092181"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(22)00849-8"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13061423"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/hematolrep15020035"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2023.2208747"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2023.2219470"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c00312"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab1228"}],"container-title":["Chemical Biology &amp; Drug Design"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cbdd.70062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T02:00:25Z","timestamp":1741744825000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cbdd.70062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,30]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/cbdd.70062"],"URL":"https:\/\/doi.org\/10.1111\/cbdd.70062","archive":["Portico"],"relation":{},"ISSN":["1747-0277","1747-0285"],"issn-type":[{"value":"1747-0277","type":"print"},{"value":"1747-0285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,30]]},"assertion":[{"value":"2024-12-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70062"}}