{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T18:46:06Z","timestamp":1779907566682,"version":"3.53.1"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>A novel class of chalcone Mannich base derivatives <jats:bold>I<\/jats:bold><jats:sub><jats:bold>1\u20109<\/jats:bold><\/jats:sub> and <jats:bold>II<\/jats:bold><jats:sub><jats:bold>1\u201011<\/jats:bold><\/jats:sub> was synthesized, which exhibited significant antiproliferation activities in five different cancer cells. The activities of most compounds were superior to those of the positive control drug 5\u2010FU. Moreover, compared with the intermediate chalcone, their water solubility was also significantly enhanced. Among them, the most prospective compound <jats:bold>I<\/jats:bold><jats:sub><jats:bold>4<\/jats:bold><\/jats:sub> (IC<jats:sub>50<\/jats:sub>\u2009=\u20093.09\u20135.08\u2009\u03bcM for the tested cancer cells) can effectively inhibit the proliferation of A549\/DDP cells (IC<jats:sub>50<\/jats:sub>\u2009=\u20094.69\u2009\u03bcM). Further mechanistic studies revealed that it can induce apoptosis of A549 and A549\/DDP cells by arresting the G2\/M phase of the cell cycle. Although the selectivity of compound <jats:bold>I<\/jats:bold><jats:sub><jats:bold>4<\/jats:bold><\/jats:sub> between tumor cells and normal cells was not obvious, it might be a promising lead compound for lung cancer and is worthy of further investigation.<\/jats:p>","DOI":"10.1111\/cbdd.70079","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T02:37:53Z","timestamp":1741747073000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Synthesis and Antitumor Evaluation of a Novel Class of Chalcone Mannich Base Derivatives"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4970-4226","authenticated-orcid":false,"given":"Bing","family":"He","sequence":"first","affiliation":[{"name":"College of Pharmacy, Anhui University of Chinese Medicine  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010zhou","family":"Tan","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Anhui University of Chinese Medicine  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010bo","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Anhui University of Chinese Medicine  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Anhui University of Chinese Medicine  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010qin","family":"He","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Anhui University of Chinese Medicine  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.104629"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.24627"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.07.037"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959\u20108049(14)50282\u20101"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/1061186X.2020.1853759"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.111954"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232415518"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.14389"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2011.10.074"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2013.158"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22010036"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.Bioorg.2020.104360"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25194362"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.07.058"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570163819666220613153225"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044\u2010020\u201002590\u20109"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11030\u2010023\u201010706\u20107"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.14159\/j.cnki.0441\u20103776.2024.02.008"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2018.9344"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570180817999200520123510"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114920"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.9b03077"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2023.106660"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm5016507"}],"container-title":["Chemical Biology &amp; Drug Design"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cbdd.70079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T08:27:22Z","timestamp":1745137642000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cbdd.70079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/cbdd.70079"],"URL":"https:\/\/doi.org\/10.1111\/cbdd.70079","archive":["Portico"],"relation":{},"ISSN":["1747-0277","1747-0285"],"issn-type":[{"value":"1747-0277","type":"print"},{"value":"1747-0285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2024-12-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70079"}}