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These bacteria feature effective efflux pumps and possess lipopolysaccharides in their outer membranes, as well as a thin peptidoglycan layer measuring 5\u201310\u2009nm in thickness. <jats:styled-content style=\"fixed-case\"><jats:italic>Acinetobacter baumannii<\/jats:italic><\/jats:styled-content> (<jats:styled-content style=\"fixed-case\"><jats:italic>A. baumannii<\/jats:italic><\/jats:styled-content>), a Gram\u2010negative bacterium, is a significant contributor to serious infections acquired in hospitals and communities, representing a substantial risk to human health. This bacterium has developed resistance to nearly all existing antibiotics, and in the past 50\u2009years, no new antibacterial class has been introduced for treating <jats:styled-content style=\"fixed-case\"><jats:italic>A. baumannii<\/jats:italic><\/jats:styled-content> infections, highlighting an urgent necessity for the development of new antibacterials. The unique structural framework and adaptable features of the pyrazole ring attract researchers to develop new antibiotics. The present study outlines the advancements made over the last decade in pyrazole\u2010containing derivatives that exhibit a wide range of antibacterial activity against various bacterial strains. Specifically, we discuss the effectiveness of diverse pyrazole derivatives against multidrug\u2010resistant <jats:styled-content style=\"fixed-case\"><jats:italic>A. baumannii<\/jats:italic><\/jats:styled-content> strains and explore various aspects of the structure\u2013activity relationship (SAR). This compilation of data could serve as an excellent platform for designing and developing new pyrazole\u2010based small molecules to target the growth of <jats:styled-content style=\"fixed-case\"><jats:italic>A. baumannii<\/jats:italic><\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/cbdd.70092","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T05:01:24Z","timestamp":1742878884000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Pyrazoles: A Master Key to Tackle Multidrug\u2010Resistant <i>Acinetobacter baumannii<\/i> and Its Structure Activity Relationship Studies"],"prefix":"10.1111","volume":"105","author":[{"given":"Saraswati","family":"Sharma","sequence":"first","affiliation":[{"name":"Faculty of Science and Technology The ICFAI University Raipur  Durg Chhattisgarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahana","family":"Raju","sequence":"additional","affiliation":[{"name":"Department of Physics, GSSS Institute of Engineering and Technology for Women, Metagalli, Mysuru Visvesvaraya Technological University  Belagavi Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh Kumar","family":"Verma","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Yulin University  Yulin Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Kamal","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Jammu  Jammu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rameshwari","family":"Verma","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Yulin University  Yulin Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piyush Kumar","family":"Thakur","sequence":"additional","affiliation":[{"name":"Faculty of Science and Technology The ICFAI University Raipur  Durg Chhattisgarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4378-9833","authenticated-orcid":false,"given":"Kothanahally S.","family":"Sharath Kumar","sequence":"additional","affiliation":[{"name":"Department of Studies in Chemistry, Manasagangotri University of Mysore  Mysuru India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,24]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"739","article-title":"Synthesis, Antimicrobial, Antioxidant and Docking Study of Some Novel 3,5\u2010Disubstituted\u20104,5\u2010Dihydro\u20101H\u2010Pyrazoles Incorporating Imine Moiety","volume":"62","author":"Abid S.","year":"2019","journal-title":"Egyptian Journal of Chemistry"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/10.4.677"},{"key":"e_1_2_8_4_1","first-page":"529","article-title":"Novel Acrylamide\u2010Pyrazole Conjugates: Design, Synthesis and Antimicrobial Evaluation","volume":"67","author":"Abu\u2010Zaied M. 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