{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T09:19:26Z","timestamp":1781774366783,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Quercetin (QCT) shows great therapeutic potential for hyperuricemia (HUA) associated with gouty arthritis (GA). However, the underlying mechanism of QCT in inhibiting the progression of HUA and GA remains unclear. HUA mouse model was established by injection of oteracil potassium (OXO) combined with ethambutol (EMB). The GA mouse model was established by intraarticular injection of sodium urate (MSU). MSU\u2010induced HK\u20102 cells as well as lipopolysaccharide (LPS) and MSU\u2010induced THP\u20101\/M0 macrophages were used as cell models. The ankle perimeter of each mouse was measured to evaluate ankle swelling. The study also detected serum levels of uric acid (UA), tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), interleukin (IL)\u20101\u03b2 (IL\u20101\u03b2), and IL\u20106 and analyzed the pathological conditions of synovial tissues and renal tissues. QCT treatment inhibited ankle joint swelling, TNF\u2010\u03b1, IL\u20101\u03b2, and IL\u20106 serum levels as well as UA production in HUA and GA mice. Treatment with QCT inhibited oxidative stress in the renal tissues of HUA and GA mice and MSU\u2010induced HK\u20102 cells. QCT treatment inhibited the inflammatory response in LPS and MSU\u2010induced THP\u20101\/M0 macrophages. QCT treatment inactivated the NOD\u2010like receptor thermal protein domain associated protein 3 (NLRP3)\/nuclear factor kappa\u2010B (NF\u2010\u03baB) pathway. QCT inactivated the NLRP3\/NF\u2010\u03baB signaling pathway to prevent HUA associated with GA.<\/jats:p>","DOI":"10.1111\/cbdd.70103","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T07:41:46Z","timestamp":1744702906000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Quercetin Prevents Hyperuricemia Associated With Gouty Arthritis by Inactivating the <scp>NLRP3<\/scp>\/<scp>NF<\/scp>\u2010<scp>\u03baB<\/scp> Signaling Pathway"],"prefix":"10.1111","volume":"105","author":[{"given":"Qingliang","family":"Meng","sequence":"first","affiliation":[{"name":"Department of Rheumatism Henan Povince Hospital of TCM  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyang","family":"Song","sequence":"additional","affiliation":[{"name":"Academy of Orthopedics and Traumatology Henan University of Chinese Medicine  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfu","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Rheumatism Henan Povince Hospital of TCM  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiakang","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Rheumatism Henan Povince Hospital of TCM  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junping","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Rheumatism Henan Povince Hospital of TCM  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Academy of Orthopedics and Traumatology Henan University of Chinese Medicine  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Academy of Orthopedics and Traumatology Henan University of Chinese Medicine  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zelin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Academy of Orthopedics and Traumatology Henan University of Chinese Medicine  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuzhao","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic DiseasesI Henan Povince Hospital of TCM  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.114068"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.591803"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1045309"},{"issue":"9","key":"e_1_2_9_5_1","first-page":"533","article-title":"Gout: Rapid Evidence Review","volume":"102","author":"Clebak K. 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