{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:10:51Z","timestamp":1790028651168,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["BT\/PR40165\/BTIS\/137\/12\/2021"],"award-info":[{"award-number":["BT\/PR40165\/BTIS\/137\/12\/2021"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["CRG\/2021\/004937"],"award-info":[{"award-number":["CRG\/2021\/004937"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Emergence of life\u2010threatening fungal infections like systemic candidiasis concurrently with bacterial infections and limitations of current antifungal therapies warrant the discovery of novel inhibitors. We identified besifloxacin (BS), an FDA\u2010approved antibacterial, as a potent antifungal inhibitor. A combination of besifloxacin with fluconazole showed a positive synergy (\u03b4\u2009=\u200929.58) resulting in 80% inhibition of microbial growth. BS was able to reduce the MIC of FLC from 2\u2009mg\/L to 0.5\u2009mg\/L when used in combination. Additionally, in murine systemic\n                    <jats:italic>Candida<\/jats:italic>\n                    infection, BS reduced fungal load by 83% in mice kidneys at a dose of 100\u2009mg\/kg\/day. The findings demonstrated the antifungal potential of BS, proposing its use in combination therapy with fluconazole to combat resistance through alternative mechanisms.\n                  <\/jats:p>","DOI":"10.1111\/cbdd.70138","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T10:51:44Z","timestamp":1749725504000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Identification and Evaluation of Besifloxacin as Repurposed Antifungal Drug in Combination With Fluconazole Against\n                    <scp>\n                      <i>Candida albicans<\/i>\n                    <\/scp>"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7806-2901","authenticated-orcid":false,"given":"Shuvechha","family":"Chakraborty","sequence":"first","affiliation":[{"name":"Biomedical Informatics Centre ICMR\u2010National Institute for Research in Reproductive and Child Health  Mumbai Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameya","family":"Pawaskar","sequence":"additional","affiliation":[{"name":"Biomedical Informatics Centre ICMR\u2010National Institute for Research in Reproductive and Child Health  Mumbai Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddhanath","family":"Metkari","sequence":"additional","affiliation":[{"name":"Experimental Animal Facility ICMR\u2010National Institute for Research in Reproductive and Child Health  Mumbai Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taruna","family":"Madan","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3766-6757","authenticated-orcid":false,"given":"Susan","family":"Idicula\u2010Thomas","sequence":"additional","affiliation":[{"name":"Biomedical Informatics Centre ICMR\u2010National Institute for Research in Reproductive and Child Health  Mumbai Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/9781555819286.ch5"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745\u20106150\u20107\u201012"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/ecosalplus.esp\u20100010\u20102014"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.22015"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof4040134"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S275258"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00684\u201020"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","unstructured":"Festing M. 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