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This study aimed to investigate the potential effects and regulatory mechanisms of AP\u201013 in asthma. An ovalbumin (OVA)\u2010induced murine asthma model was established to evaluate oxidative stress biomarkers, inflammatory cell infiltration (eosinophils, neutrophils, and lymphocytes), and Th2 cytokine production (IL\u20104, IL\u20105, IL\u201013) using enzyme\u2010linked immunosorbent assay (ELISA). Lung histopathology was assessed by hematoxylin and eosin (H&amp;E) staining, while epithelial\u2013mesenchymal transition (EMT) markers were quantified through reverse transcription quantitative polymerase chain reaction (RT\u2010qPCR), western blot analysis, and immunohistochemistry. Our results demonstrated that AP\u201013 could alleviate oxidative stress, decrease the number of inflammatory cells, inhibit the release of Th2 cytokines, improve pathological changes, and suppress EMT in asthmatic mice. Collectively, our data suggest that AP\u201013 could be a promising therapeutic agent for the treatment of asthma.<\/jats:p>","DOI":"10.1111\/cbdd.70142","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T03:15:33Z","timestamp":1750821333000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Apelin\u201013 Protects Against Airway Inflammation, Oxidative Stress, and Epithelial\u2013Mesenchymal Transition in a Chronic Asthma Model"],"prefix":"10.1111","volume":"105","author":[{"given":"Huifeng","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine No.964 Hospital of People's Liberation Army  Changchun Jilin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine No.964 Hospital of People's Liberation Army  Changchun Jilin 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