{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T19:21:54Z","timestamp":1784056914514,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["6242018"],"award-info":[{"award-number":["6242018"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Vitamin E can exert either a cancer preventive effect or improve the therapeutic efficacy of chemotherapeutic drugs against multiple types of cancer. Ample evidence suggests that the cancer preventive activity of vitamin E is form\u2010dependent; however, it is not clear whether its chemosensitization effect is also influenced by its forms. The objectives of this study were to investigate whether the eight natural forms of vitamin E produced differential sensitization effects on cancer chemotherapeutic drugs and to address whether the chemosensitization effect of vitamin E was associated with its inhibitory effect on programmed cell death ligand 1 (PD\u2010L1) signaling. We carried out a comparative evaluation of the chemosensitization effect of eight vitamin E forms using paclitaxel as a representative therapeutic drug and breast\/prostate cancer as the representative types of cancer. Results showed that the sensitization effect of vitamin E on chemotherapeutic drugs was also form\u2010dependent, with \u03b4\u2010tocotrienol (\u03b4\u2010T3) as the most effective one for sensitizing breast and prostate cancer cells to paclitaxel, mechanistically associated with its ability to suppress PD\u2010L1\u2010mediated tumor\u2010promoting signaling. The findings provided novel insights into understanding the sensitization effect of vitamin E and its related mechanisms and support that \u03b4\u2010T3 is the best candidate as an enhancer of taxanes among the eight forms.<\/jats:p>","DOI":"10.1111\/cbdd.70143","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T13:18:48Z","timestamp":1749734328000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["\u03b4\u2010Tocotrienol Potentiates Breast and Prostate Cancer Cells to Paclitaxel via Suppressing <scp>PD<\/scp>\u2010<scp>L1<\/scp>\u2010Mediated Cancer\u2010Promoting Signaling"],"prefix":"10.1111","volume":"105","author":[{"given":"Zhenou","family":"Sun","sequence":"first","affiliation":[{"name":"College of Food Science and Nutritional Engineering China Agricultural University  Beijing China"},{"name":"College of Food Science and Nutritional Engineering Tianjin University of Science 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