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The study aims to evaluate the anti\u2010influenza viral pneumonia effects of volatile monomers patchouli alcohol (PA), carvacrol (CV),\n                    <jats:italic>p\u2010<\/jats:italic>\n                    Cymene (PC), eucalyptol (EC) and their formulations from various aspects through the influenza virus A\/PR\/8\/34 (H1N1) infection experiment in\u00a0vivo and in\u00a0vitro and carry out in\u2010depth studies on the anti\u2010inflammatory mechanisms. In this study, we found that all four volatile monomers mentioned above could exert antiviral effects by suppressing pulmonary viral load and lung index and improving lung lesions in mice with influenza pneumonia. In addition, elevated levels of cytokines and chemokines in the serum were suppressed, the proportion of T\u2010lymphocytes in the peripheral blood was altered, and antioxidative stress indices were improved, whose mechanism of action related to anti\u2010inflammation, possibly acting on the Toll\u2010Like Receptor 4\/Nuclear Factor\u2010\u03baB\/nucleotide\u2010binding domain leucine\u2010rich repeat and pyrin domain\u2010containing receptor 3 (TLR4\/NF\u2010\u03baB\/NLRP3) pathway. The study provides an experimental basis for volatile monomers and their formulations of aromatic herbs for treating influenza virus pneumonia.\n                  <\/jats:p>","DOI":"10.1111\/cbdd.70150","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T11:50:20Z","timestamp":1754308220000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Inhibition Effects of Patchouli Alcohol, Carvacrol,\n                    <i>p<\/i>\n                    \u2010Cymene, Eucalyptol and Their Formulations Against Influenza Virus Pneumonia Through\n                    <scp>TLR4<\/scp>\n                    \/\n                    <scp>NF<\/scp>\n                    \u2010\n                    <scp>\u03baB<\/scp>\n                    \/\n                    <scp>NLRP3<\/scp>\n                    Signaling Pathway"],"prefix":"10.1111","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0586-2075","authenticated-orcid":false,"given":"Ruilin","family":"Lv","sequence":"first","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing China"},{"name":"Xinyang Vocational and Technical College  Xinyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinming","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linze","family":"Li","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruying","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing China"},{"name":"Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3855-3359","authenticated-orcid":false,"given":"Jianjun","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9048-2829","authenticated-orcid":false,"given":"Linyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00216"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.109130"},{"issue":"2","key":"e_1_2_9_4_1","first-page":"250","article-title":"Determination of Volatile Oil by GC\u2010MS and Evaluation of Heavy Metals Residue in Fructus Amomi From Different Producing Areas","volume":"27","author":"Ao H.","year":"2016","journal-title":"Traditional Chinese Drug Research and Clinical Pharmacology"},{"issue":"8","key":"e_1_2_9_5_1","first-page":"127","article-title":"Comparative Study of Chemical Composition and Biological Activity of Essential Oil From Four Species of Mentha L. 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