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Their antioxidant (ABTS, DPPH, Cuprac), cholinesterase inhibition (AChE, BuChE), and anticancer (Caco\u20102, PC3) activities were evaluated. In DPPH assays, compounds 13, 6, and 11 showed superior antioxidant activity compared to \u03b1\u2010tocopherol and BHT. Compound 6 exhibited the highest ABTS activity, while compound 9 excelled in Cuprac assays. For cholinesterase inhibition, compounds 8 and 13 outperformed Galantamine against AChE, and compound 9 showed the strongest BuChE inhibition. Antiproliferative studies revealed compound 13's effectiveness against PC3 and compound 9 against Caco\u20102. Comprehensive ADMET analysis indicated favorable pharmaceutical properties, including oral absorption via the BBB and GI tract. In silico molecular docking supported these findings, confirming the therapeutic potential of these hybrid structures.<\/jats:p>","DOI":"10.1111\/cbdd.70155","type":"journal-article","created":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T06:29:26Z","timestamp":1753511366000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Synthesis and Bioactivity Evaluation of Novel Sulfonamide\u20101,2,3\u2010Triazole Hybrids:\n                    <i>In Vitro<\/i>\n                    and\n                    <i>In Silico<\/i>\n                    Studies"],"prefix":"10.1111","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2020-5965","authenticated-orcid":false,"given":"Mustafa","family":"\u00c7e\u015fme","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences Kahramanmaras Sutcu Imam University  Kahramanmaras Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4305-9638","authenticated-orcid":false,"given":"Sultan","family":"Onur","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences Kahramanmaras Sutcu Imam University  Kahramanmaras Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4568-5782","authenticated-orcid":false,"given":"Fatma Bet\u00fcl","family":"\u00d6zgeri\u015f","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Faculty of Health Sciences Ataturk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2222-2133","authenticated-orcid":false,"given":"Ferhan","family":"T\u00fcmer","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences Kahramanmaras Sutcu Imam University  Kahramanmaras Turkey"},{"name":"Department of Chemical Engineering, Faculty of Engineering Kyrgyz\u2010Turkish Manas University  Bishkek Kyrgyz Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2018.04.008"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202100158"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.946134"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2022.109956"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2017.05.014"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2005.09.037"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2022.134073"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetasy.2009.03.021"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2022.133763"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2008.02.047"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep42717"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201600182"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2012.12.046"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/0118715249278489231128042135"},{"key":"e_1_2_8_16_1","unstructured":"Eggler J. 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