{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T12:41:45Z","timestamp":1775997705769,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Platinum\u2010based and pyrimidine drugs are first\u2010line treatments for gastric cancer (GC), but their efficacy is often affected by drug resistance. High spalt\u2010like transcription factor 4 (SALL4) expression is associated with poor prognosis, but its role in 5\u2010fluorouracil (5\u2010FU) resistance is not yet clear. In this study, we investigated the effect of SALL4 on 5\u2010FU resistance in GC cells by bioinformatics analysis, real\u2010time quantitative reverse transcription polymerase chain reaction, cell counting kit\u20108, colony formation assay, and western blot. The results showed that SALL4 was highly expressed in GC and significantly correlated with the fatty acid oxidation (FAO) pathway. Knockdown of SALL4 resulted in a notable attenuation of cellular proliferative capacity and heightened susceptibility to 5\u2010FU resistance in GC cells, while overexpression of SALL4 enhanced 5\u2010FU resistance. Rescue assays confirmed that SALL4 fostered 5\u2010FU resistance in GC cells by enhancing FAO. Our research confirmed that SALL4 promoted the resistance of GC cells to 5\u2010FU by enhancing the FAO pathway. This suggests that drug development targeting SALL4 may help overcome chemotherapy resistance in GC.<\/jats:p>","DOI":"10.1111\/cbdd.70158","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T05:25:00Z","timestamp":1753334700000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spalt\u2010Like Transcription Factor 4 Mediates Fatty Acid Oxidation to Foster 5\u2010Fluorouracil Resistance in Gastric Cancer Cells"],"prefix":"10.1111","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9722-6394","authenticated-orcid":false,"given":"Yong","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery Nanbu County People's Hospital  Nanchong Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanmin","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Nanbu County 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