{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T23:26:12Z","timestamp":1783639572494,"version":"3.55.0"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>A novel series of triazole\u2010linked indole derivatives was designed, synthesized, and evaluated as soluble epoxide hydrolase inhibitors (sEHIs) for their potential anticancer activity. These compounds exhibit strong binding affinity within the hydrophobic pockets of sEH, with compounds 9a and 9b emerging as the most potent inhibitors, achieving IC\u2085\u2080 values of 0.270\u2009\u00b1\u20090.014\u2009nM and 0.358\u2009\u00b1\u20090.03\u2009nM, respectively, in\u00a0vitro. In addition, both compounds display significant cytotoxic activity against HeLa cells, with IC\u2085\u2080 values of 5.366\u2009\u00b1\u20090.91\u2009\u03bcM and 5.686\u2009\u00b1\u20090.73\u2009\u03bcM, respectively. Molecular docking studies, using the 1ZD5 crystal structure, reveal key hydrogen bond interactions analogous to those observed with 12\u2010(3\u2010adamantan\u20101\u2010yl\u2010ureido)\u2010dodecanoic acid (AUDA), providing mechanistic insights into their inhibitory activity. Structure\u2013activity relationship (SAR) analysis further informs the rational optimization of these derivatives for enhanced potency. Overall, these findings highlight triazole\u2010linked indole derivatives as promising lead candidates for the development of sEH\u2010targeted anticancer therapeutics.<\/jats:p>","DOI":"10.1111\/cbdd.70164","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T11:06:26Z","timestamp":1756897586000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Novel Triazole\u2010Linked Indole Derivatives as Potent Soluble Epoxy Hydrolase Inhibitors With Promising Anticancer Activity"],"prefix":"10.1111","volume":"106","author":[{"given":"Vijaykumar D.","family":"Nimbarte","sequence":"first","affiliation":[{"name":"Department of Pharmacy Birla Institute of Technology and Science (BITS) Pilani  Medchal Telangana India"},{"name":"Institute for Organic Chemistry and Chemical Biology Center for Biomolecular Magnetic Resonance (BMRZ) Goethe University Frankfurt Max\u2010von\u2010Laue\u2010Stra\u00dfe 7  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreya S.","family":"Sonak","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Birla Institute of Technology and Science (BITS) Pilani  Medchal Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharda A.","family":"Ishwarkar","sequence":"additional","affiliation":[{"name":"Department of Chemistry Govindrao Wanjari College of Engineering and Technology  Nagpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharat","family":"Rathod","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Birla Institute of Technology and Science (BITS) Pilani  Medchal Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saiprem","family":"Nehlani","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Birla Institute of Technology and Science (BITS) Pilani  Medchal Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI43195"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01886"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm500694p"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-013-0817-8"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202000835"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.43639"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-021-02752-3"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm201468j"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2017.06.006"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S241893"}],"container-title":["Chemical Biology &amp; Drug Design"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cbdd.70164","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T11:57:16Z","timestamp":1758801436000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cbdd.70164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/cbdd.70164"],"URL":"https:\/\/doi.org\/10.1111\/cbdd.70164","archive":["Portico"],"relation":{},"ISSN":["1747-0277","1747-0285"],"issn-type":[{"value":"1747-0277","type":"print"},{"value":"1747-0285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2025-04-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70164"}}