{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T16:01:14Z","timestamp":1776096074324,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This study aimed to investigate the effects and mechanisms of Ganoderic acid A (GAA) on lung injury associated with systemic inflammatory response syndrome (SIRS). Forty Sprague Dawley rats were divided into four groups: Control group, GAA group (GAA, 40\u2009mg\/kg), lipopolysaccharide (LPS) group (LPS, 10\u2009mg\/kg), and LPS\u2009+\u2009GAA group. Lung tissue, bronchoalveolar lavage fluid (BALF), and blood samples were analyzed for cell counts, protein levels, and histology, inflammatory cytokines, oxidative stress markers, and macrophage polarization. Western blot was used to assess the TLR4\/NF\u2010\u03baB pathway. GAA treatment significantly attenuated LPS\u2010induced lung injury, as shown by reduced lung tissue water content and BALF protein levels. Histological analysis confirmed less severe lung injury in GAA\u2010treated rats. GAA decreased inflammatory cell numbers in BALF, lowered inflammatory cytokine levels in serum and BALF, and reduced oxidative stress levels in lung tissue. Flow cytometry indicated that GAA promoted M2 macrophage polarization, and Western blot analysis revealed inhibition of TLR4\/NF\u2010\u03baB pathway activation. GAA ameliorates lung injury induced by sepsis\u2010related SIRS in rats through anti\u2010inflammatory, anti\u2010oxidative, and immunomodulatory effects, supporting its potential therapeutic value in sepsis treatment.<\/jats:p>","DOI":"10.1111\/cbdd.70172","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T01:47:34Z","timestamp":1760406454000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Improving Lung Injury in Sepsis\u2010Related Systemic Inflammatory Response Syndrome Through Regulation of the\n                    <scp>TLR4<\/scp>\n                    \/\n                    <scp>NF<\/scp>\n                    \u2010\n                    <scp>\u03baB<\/scp>\n                    Pathway and Macrophage Polarization by Ganoderic Acid A"],"prefix":"10.1111","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3048-2296","authenticated-orcid":false,"given":"Mingjie","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Renmin Hospital Hubei University of Medicine  Shiyan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianru","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Renmin Hospital Hubei University of Medicine  Shiyan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Che","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Renmin Hospital Hubei University of Medicine  Shiyan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0749\u20100704(05)70106\u20108"},{"key":"e_1_2_12_3_1","unstructured":"Chakraborty R. K. andB.Burns.2024.\u201cSystemic Inflammatory Response Syndrome.\u201d StatPearls. Treasure Island (FL) Ineligible Companies. Disclosure: Bracken Burns Declares No Relevant Financial Relationships With Ineligible Companies."},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6336"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41232\u2010016\u20100029\u2010y"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13010024"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000052"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12223"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.11.026"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2021.114422"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj\u20102016\u2010134519"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2021.09.012"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272\u2010020\u201001256\u20109"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc13155"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753\u2010021\u201001468\u20101"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2015.114"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/761264"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11112302"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20190301"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1590\/1414\u2010431X20198092"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/137914"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201708007"},{"issue":"14","key":"e_1_2_12_24_1","first-page":"2611","article-title":"Protective Effect of Unfractionated Heparin on Acute Lung Injury Induced by Sepsis in Rats","volume":"47","author":"Wang Y.","year":"2022","journal-title":"Modern Preventive Medicine"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000505297"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0394632015593228"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/1419631"},{"issue":"17","key":"e_1_2_12_28_1","first-page":"3334","article-title":"Analysis of the Correlation of Circulating Follicular Helper T Cells Subsets With Clinical Features of Myasthenia Gravis","volume":"16","author":"Yong\u2010Xiang Y.","year":"2016","journal-title":"Progress in Modern Biomedicine"},{"issue":"3","key":"e_1_2_12_29_1","first-page":"88","article-title":"Therapeutic Potentials of Superoxide Dismutase","volume":"12","author":"Younus H.","year":"2018","journal-title":"International Journal of Health Sciences"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.585146"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology11020155"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.14331"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.80250"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753\u2010021\u201001590\u20100"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2022.11237"}],"container-title":["Chemical Biology &amp; Drug Design"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cbdd.70172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:19:21Z","timestamp":1761657561000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cbdd.70172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/cbdd.70172"],"URL":"https:\/\/doi.org\/10.1111\/cbdd.70172","archive":["Portico"],"relation":{},"ISSN":["1747-0277","1747-0285"],"issn-type":[{"value":"1747-0277","type":"print"},{"value":"1747-0285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-06-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70172"}}