{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T08:07:50Z","timestamp":1771142870308,"version":"3.50.1"},"reference-count":62,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The vital process of CO\n                    <jats:sub>2<\/jats:sub>\n                    hydration in all living things is catalyzed by carbonic anhydrases (CAs, EC 4.2.1.1), which are actively involved in the control of numerous pathological and physiological situations. A number of coumarin\u2010based sulfonamides (18) were examined as potential CA inhibitors. Their inhibitory activity was assessed against the cytosolic human isoforms hCA I, hCA II, and the transmembrane hCA IX as well as against three fungal CAs:\n                    <jats:italic>Malassezia globosa<\/jats:italic>\n                    (MgCA),\n                    <jats:italic>Malassezia pachydermatis<\/jats:italic>\n                    (MpaCA), and\n                    <jats:italic>Malassezia restricta<\/jats:italic>\n                    (MreCA). Additionally, the binding mechanism of this family of chemicals within the active site of hCA IX was investigated using computational approaches. Compounds showed interesting inhibitory activity mainly against two fungal strains,\n                    <jats:italic>Malassezia globosa<\/jats:italic>\n                    (MgCA) and\n                    <jats:italic>Malassezia pachydermatis<\/jats:italic>\n                    (MpaCA), exceeding in the first case the activity of the reference drug, and in the second, 16 out of 18 showed Ki values lower than acetozolamide. Furthermore, four compounds were more potent against hCA I than AAZ and two against hCA II. Docking studies were used to investigate the binding mode of the most active compounds against human CA isoforms.\n                  <\/jats:p>","DOI":"10.1111\/cbdd.70188","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:01:49Z","timestamp":1761804109000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Coumarin\u2010Containing Aromatic Sulfonamides With Carbonic Anhydrase Inhibitory Properties Against Human and Fungal Isoforms"],"prefix":"10.1111","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1470-7192","authenticated-orcid":false,"given":"Andrea","family":"Angeli","sequence":"first","affiliation":[{"name":"Neuro Farba Department, Sezione di Scienze Farmaceutiche Universit\u00e0 degli Studi di Firenze  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthi","family":"Petrou","sequence":"additional","affiliation":[{"name":"School of Health, Department of Pharmacy Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Kartsev","sequence":"additional","affiliation":[{"name":"InterBioScreen  Chernogolovka Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviana","family":"De Luca","sequence":"additional","affiliation":[{"name":"Istituto di Bioscienze e Biorisorse, CNR  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clemente","family":"Capasso","sequence":"additional","affiliation":[{"name":"Istituto di Bioscienze e Biorisorse, CNR  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9894-7777","authenticated-orcid":false,"given":"Athina","family":"Geronikaki","sequence":"additional","affiliation":[{"name":"School of Health, Department of Pharmacy Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4262-0323","authenticated-orcid":false,"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[{"name":"Neuro Farba Department, Sezione di Scienze Farmaceutiche Universit\u00e0 degli Studi di Firenze  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.105424"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11030-021-10230-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2023.136860"},{"key":"e_1_2_7_5_1","first-page":"38","article-title":"Studies on the Synthesis of Benzene Sulfonamides, Evaluation of Their Antimicrobial Activities, and Molecular Docking","volume":"39","author":"Ahmed M.","year":"2020","journal-title":"Latin American Journal of Pharmacy"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242316716"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25143251"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr200176r"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0908301106"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202301392"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22105082"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15030316"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202400147"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4RA01060D"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.0c00280"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11164-015-2081-7"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9090775"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja204075s"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep42717"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2010.07.051"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-019-02494-3"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.5562\/cca3266"},{"key":"e_1_2_7_23_1","first-page":"740","volume-title":"Coumarines: Chemistry & Biological Activity","author":"Garazd M. 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