{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T12:35:40Z","timestamp":1771331740880,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2020MB010"],"award-info":[{"award-number":["ZR2020MB010"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cancer is one of the most complex diseases. Its multidrug resistance and poor prognosis make the development of antitumor drugs still a difficult task. 18\u03b2\u2010glycyrrhetinic acid (18\u03b2\u2010GA) has shown great potential for tumor prevention and treatment. However, inherent defects, such as low bioavailability, limit its use. Herein, based on a molecular hybridization strategy, two series of \u03b1, \u03b2\u2010unsaturated carbonyl modified 18\u03b2\u2010GA derivatives were synthesized using 18\u03b2\u2010GA as the parent nucleus. Among them, compounds\n                    <jats:bold>9a<\/jats:bold>\n                    ,\n                    <jats:bold>9g<\/jats:bold>\n                    and\n                    <jats:bold>9i<\/jats:bold>\n                    exhibited the strongest antiproliferative activity, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values ranging from 1.52 to 3.46\u2009\u03bcM against HCT\u2010116, SH\u2010SY5Y and HepG2 cells. The key target of the three active derivatives was predicted to be human STAT3 through reverse target finding. Docking analysis proved that all three derivatives showed strong binding affinity to STAT3 in silico, suggesting potential as STAT3 inhibitors.\n                  <\/jats:p>","DOI":"10.1111\/cbdd.70190","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:14:47Z","timestamp":1761894887000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Antiproliferative Activity and Target Analysis of 18\u03b2\u2010Glycyrrhetinic Acid Derivatives Modified With \u03b1, \u03b2\u2010Unsaturated Carbonyl Groups"],"prefix":"10.1111","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4147-6974","authenticated-orcid":false,"given":"Chenmeng","family":"Xu","sequence":"first","affiliation":[{"name":"Marine College Shandong University  Weihai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"Marine College Shandong University  Weihai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Wang","sequence":"additional","affiliation":[{"name":"Marine College Shandong University  Weihai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Sustainable Chemistry for Metals and Molecules KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjun","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Sustainable Chemistry for Metals and Molecules KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deshang","family":"Li","sequence":"additional","affiliation":[{"name":"Marine College Shandong University  Weihai 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