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Sepsis, characterized as a systemic inflammatory response syndrome (SIRS), is triggered by a cytokine storm resulting from pathogenic infection and can progress to multi\u2010organ failure. This study investigates and predicts the effective molecular targets and potential mechanisms of PA in the context of sepsis through the application of network pharmacology. The identified targets were subsequently validated using an in\u00a0vitro molecular model, thereby providing a robust theoretical basis for our findings. Our results indicate that PA significantly reduced malondialdehyde (MDA) accumulation, ameliorated glutathione (GSH) depletion, enhanced glutathione peroxidase 4 (GPX4) expression, and restored mitochondrial function. Notably, PA markedly decreased prostaglandin\u2010endoperoxide synthase 2 (PTGS2) expression, which collectively suggests that PA may inhibit ferroptosis. We propose that PA may exert its inhibitory effects on ferroptosis in macrophages via modulation of PTGS2, highlighting its potential as a drug for sepsis treatment.<\/jats:p>","DOI":"10.1111\/cbdd.70196","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T11:02:39Z","timestamp":1762426959000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Investigation Into the Inhibition of Ferroptosis by Praeruptorin\u2010A in Sepsis Based on Network Pharmacology"],"prefix":"10.1111","volume":"106","author":[{"given":"Yue\u2010Ming","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine Hangzhou City University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Jing","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Hangzhou City University School of 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