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Furthermore, the crystal structure of compound\n                    <jats:bold>1647<\/jats:bold>\n                    was figured out by the single crystal X\u2010ray analysis. The in\u00a0vitro antimicrobial activity was reviewed against five species of pathogenic bacteria (\n                    <jats:italic>\n                      Escherichia\n                      <jats:styled-content style=\"fixed-case\">coli<\/jats:styled-content>\n                    <\/jats:italic>\n                    [ATCC 25922],\n                    <jats:italic>Serratia marcescens<\/jats:italic>\n                    ,\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    [ATCC 13883],\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    [ATCC 29213],\n                    <jats:italic>Enterococcus faecalis<\/jats:italic>\n                    [ATCC 2942]) and three fungal species (\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    [ATCC 24433],\n                    <jats:italic>Candida krusei<\/jats:italic>\n                    [ATCC 6258], and\n                    <jats:italic>Candida parapsilopsis<\/jats:italic>\n                    [ATCC 22019]). Compounds\n                    <jats:bold>1646<\/jats:bold>\n                    and\n                    <jats:bold>1647<\/jats:bold>\n                    with MIC of 1.95\u2009\u03bcg\/mL was found to be most active against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>E. coli<\/jats:italic>\n                    <\/jats:styled-content>\n                    (ATCC 25922). The presence of bromine or\n                    <jats:italic>tert<\/jats:italic>\n                    \u2010butyl groups in the\n                    <jats:italic>para<\/jats:italic>\n                    position of the phenyl ring increased the antibacterial activity. It has been shown by SEM study that these compounds cause deterioration in the morphology of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>E. coli<\/jats:italic>\n                    <\/jats:styled-content>\n                    . Using DFT, the X\u2010ray geometry and model geometry of compound\n                    <jats:bold>1647<\/jats:bold>\n                    were optimized and compared in terms of both energy and geometry, and it was determined that they were conformers of each other with a difference of 0.11\u2009kcal\/mol.\n                  <\/jats:p>","DOI":"10.1111\/cbdd.70199","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T11:26:07Z","timestamp":1763119567000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synthesis of New Hydrazone Derivatives, Characterization, Single Crystal X\u2010Ray, Antimicrobial,\n                    <scp>SEM<\/scp>\n                    , and\n                    <scp>DFT<\/scp>\n                    Studies"],"prefix":"10.1111","volume":"106","author":[{"given":"Hakan","family":"\u00dcnver","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science Eskisehir Technical University  Eskisehir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9619-6705","authenticated-orcid":false,"given":"Abd\u00fcllatif","family":"Karakaya","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Zonguldak B\u00fclent Ecevit University  Zonguldak Turkey"},{"name":"Department of Pharmaceutical Chemistry, Graduate School Anadolu University  Eski\u015fehir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00dclk\u00fcye Dudu","family":"G\u00fcl","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Faculty of Engineering Bilecik Seyh Edebali University  Bilecik Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3369-8690","authenticated-orcid":false,"given":"Arzu","family":"Karayel","sequence":"additional","affiliation":[{"name":"Department of Physics, Faculty of Arts and Sciences Hitit University  \u00c7orum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1879-1034","authenticated-orcid":false,"given":"Ulviye","family":"Acar \u00c7evik","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Anadolu University  Eski\u015fehir Turkey"},{"name":"Medicinal Plant, Drug and Scientific Research and Application Center (AUBIBAM) Anadolu University  Eskisehir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1515\/tjb\u20102017\u20100167"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chphi.2022.100146"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118325421"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1103\/physreva.38.3098"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.139955"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2024.121940"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c06142"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040\u20104039(00)71309\u20108"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.14590"},{"key":"e_1_2_8_11_1","unstructured":"Dassault Syst\u00e8mes BIOVIA.2019.\u201cDiscovery Studio Modeling Environment Release Dassault Syst\u00e8mes San Diego CA USA.\u201d"},{"key":"e_1_2_8_12_1","unstructured":"Dennington R. 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