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CD36 is overexpressed in various types of cancer and CD36\n                    <jats:sup>+<\/jats:sup>\n                    cancer cells display enhanced malignancy, including resistance to therapy and elevated stemness and metastatic ability. Thus, CD36 is a therapeutic target in cancer. This study aimed to discover new CD36 antagonists through virtual screening. We identified a druggable pocket in CD36 that is functionally relevant and serves as the binding site for reported antagonists. Consensus molecular docking of a chemical library containing over 25,000 drug\u2010like compounds identified 15 computational hits with structural diversity. Experimental evaluation of seven compounds revealed that compounds 8, 13, and 14 are novel inhibitors of CD36\u2010mediated palmitate and\/or oxLDL uptake in cellular models. 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