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Recent research has primarily focused on developing multi\u2010target drug designs. A new series of fluorinated 1,3,4\u2010oxadiazole\u20101,2,3\u2010triazole hybrids was designed and synthesized with high yield utilizing the substructure approach. The newly synthesized compounds were characterized using spectral analyses, including NMR (\n                    <jats:sup>1<\/jats:sup>\n                    H,\n                    <jats:sup>13<\/jats:sup>\n                    C, and\n                    <jats:sup>19<\/jats:sup>\n                    F), mass spectrometry (MS), and high\u2010performance liquid chromatography (HPLC). Additionally, their in\u00a0vitro anti\u2010cancer activity was evaluated against lung cancer A549 and cervical cancer HeLa cell lines. The results indicated that a number of the synthesized hybrids showed encouraging cytotoxic effects, significantly reducing cell proliferation in comparison to the control groups. Compounds (\n                    <jats:bold>7c<\/jats:bold>\n                    ), (\n                    <jats:bold>9a<\/jats:bold>\n                    ), and (\n                    <jats:bold>9b<\/jats:bold>\n                    ) exhibited high cytotoxicity against lung cancer cell lines, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 19.47 to 21.65\u2009\u03bcg\/mL. Compound (\n                    <jats:bold>7c<\/jats:bold>\n                    ) exhibited significant activity against lung cancer, with an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 19.47\u2009\u03bcg\/mL. Compounds (\n                    <jats:bold>7c<\/jats:bold>\n                    ), (\n                    <jats:bold>9a<\/jats:bold>\n                    ), and (\n                    <jats:bold>9b<\/jats:bold>\n                    ) exhibited broad cytotoxic effects against the HeLa cell line, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 17.07\u2009\u03bcg\/mL for (\n                    <jats:bold>7c<\/jats:bold>\n                    ), 19.21\u2009\u03bcg\/mL for (\n                    <jats:bold>9a<\/jats:bold>\n                    ), and 20.85\u2009\u03bcg\/mL for (\n                    <jats:bold>9b<\/jats:bold>\n                    ). Compound (\n                    <jats:bold>7b<\/jats:bold>\n                    ) outperformed the other compounds in anticancer activity against the cervical carcinoma HeLa cell line. In silico drug\u2010like properties indicated that they could be promising molecular frameworks for further studies. The binding modes of compounds (\n                    <jats:bold>9a<\/jats:bold>\n                    ) and (\n                    <jats:bold>9b<\/jats:bold>\n                    ) were analyzed, revealing the most favorable poses of these compounds within the active site of the tested EGFR (PDB ID: 8SC7) through a molecular docking study. Molecular dynamics simulations of compounds (\n                    <jats:bold>9a<\/jats:bold>\n                    ) and (\n                    <jats:bold>9b<\/jats:bold>\n                    ) highlighted the key amino acids in the enzyme's active region and provided insight into the mechanism of enzyme interactions.\n                  <\/jats:p>","DOI":"10.1111\/cbdd.70225","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T18:27:20Z","timestamp":1765996040000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Discovery of Novel Oxadiazole\u2010Triazole Hybrids as Lung and Cervical Cancer Agents: Synthesis, Docking, Biological Evaluation, and\n                    <scp>SAR<\/scp>\n                    Studies"],"prefix":"10.1111","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3123-4610","authenticated-orcid":false,"given":"Venkatraman","family":"Hegde","sequence":"first","affiliation":[{"name":"Centre for Nano and Material Sciences Jain (Deemed\u2010To\u2010Be University)  Bangalore Karnataka India"},{"name":"Aurigene Pharmaceutical Services, KIADB Industrial Area  Bangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raveendra Madhukar","family":"Bhat","sequence":"additional","affiliation":[{"name":"Centre for Nano and Material Sciences Jain (Deemed\u2010To\u2010Be University)  Bangalore Karnataka India"},{"name":"Aurigene Pharmaceutical Services, KIADB Industrial Area  Bangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gangadhar V.","family":"Muddapur","sequence":"additional","affiliation":[{"name":"Department of Physics KLE Technological University  Hubli Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun K.","family":"Shettar","sequence":"additional","affiliation":[{"name":"Multidisciplinary Research Unit, Karnataka Medical College and Research Institute  Hubli Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy H.","family":"Hoskeri","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics and Biotechnology Karnataka State Akkamahadevi Women University  Vijayapura Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad Rashad","family":"Sindi","sequence":"additional","affiliation":[{"name":"Division of Clinical Biochemistry, Department of Basic Medical Sciences, College of Medicine University of Jeddah  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7195-3288","authenticated-orcid":false,"given":"Al\u2010Anood M.","family":"Al\u2010Dies","sequence":"additional","affiliation":[{"name":"Department of Chemistry Umm Al\u2010Qura University, Al\u2010Qunfudah University College  Makkah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasad P. 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