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In this study, novel 1,2,3\u2010triazole derivatives 4\u2010substituted with salicylic esters and their salts were synthesized and evaluated against\n                    <jats:italic>L. amazonensis<\/jats:italic>\n                    . While neutral compounds were inactive, their salts effectively inhibited both promastigote and intracellular amastigote growth. Compound\n                    <jats:bold>7<\/jats:bold>\n                    exhibited the highest antileishmanial activity and selectivity (IC\n                    <jats:sub>50<\/jats:sub>\n                    against amastigotes of 6.23\u2009\u00b1\u20090.35\u2009\u03bcM; SI of 17.81), surpassing miltefosine, the positive control. Additionally, this compound exhibited no hemolytic effect. Studies further demonstrated that at early time points (6\u2009h), treatment with compound\n                    <jats:bold>7<\/jats:bold>\n                    led to a marked increase in total ROS and mitochondrial superoxide levels, although no change in mitochondrial membrane potential was detected, indicating an initial oxidative imbalance without immediate effects on \u0394\u03a8m. However, after 24\u2009h of treatment, this sustained oxidative stress resulted in pronounced mitochondrial membrane potential hyperpolarization, while elevated ROS levels persisted. Throughout these assays, plasma membrane integrity remained unaffected in treated\n                    <jats:italic>L. amazonensis<\/jats:italic>\n                    promastigotes. In silico analyses suggested favorable pharmacokinetic properties and oral bioavailability. Collectively, these findings highlight compound\n                    <jats:bold>7<\/jats:bold>\n                    as a promising candidate for further studies, including in\u00a0vivo assays using murine models of leishmaniasis.\n                  <\/jats:p>","DOI":"10.1111\/cbdd.70227","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T07:10:33Z","timestamp":1766473833000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mitochondrial Dysfunction Induced by a Novel Salicylate\u2010Based 1,2,3\u2010Triazole Salt With Potent Antileishmanial Activity"],"prefix":"10.1111","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6695-9592","authenticated-orcid":false,"given":"Bruno A.","family":"De Oliveira","sequence":"first","affiliation":[{"name":"Department of Chemistry, Institute of Exact Sciences Federal University of Juiz de Fora  Juiz de Fora Minas Gerais 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