{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T18:37:35Z","timestamp":1769539055604,"version":"3.49.0"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T00:00:00Z","timestamp":1767398400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Mitragyna diversifolia<\/jats:italic>\n                    is commonly used to cure diarrhoea in the Bandarban region. However, the impact of anti\u2010inflammatory properties and underlying material basis remains unexplored. This study aimed to determine the anti\u2010inflammatory and antidiabetic potential of metabolites from\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>M.\u2009diversifolia<\/jats:italic>\n                    <\/jats:styled-content>\n                    . The results indicated that 2,4\u2010di\u2010tert\u2010bylphenol (\n                    <jats:bold>8<\/jats:bold>\n                    ), cryptotanshinone (\n                    <jats:bold>9<\/jats:bold>\n                    ), and dihydrotanshinone I (\n                    <jats:bold>10<\/jats:bold>\n                    ) not only effectively inhibited LPS\u2010induced NO production but also demonstrated potential antidiabetic activities by promoting glucose uptake. Network pharmacological analysis, molecular docking, and molecular dynamics simulation revealed that AKT1 was a crucial target for the anti\u2010inflammatory and antidiabetic effects of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>M.\u2009diversifolia<\/jats:italic>\n                    <\/jats:styled-content>\n                    . At the same time, molecular docking analysis showed that compounds\n                    <jats:bold>8<\/jats:bold>\n                    ,\n                    <jats:bold>9<\/jats:bold>\n                    , and\n                    <jats:bold>10<\/jats:bold>\n                    possessed superior binding capacities with AKT1 (\u22127.3, \u221211.9, and \u221211.7\u2009kcal\/mol, respectively). Collectively, this study preliminarily clarified the possible material basis and mechanism of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>M.\u2009diversifolia<\/jats:italic>\n                    <\/jats:styled-content>\n                    to prevent inflammation and diabetes. Further research is needed to determine the in\u00a0vivo conditions of compounds\n                    <jats:bold>8<\/jats:bold>\n                    ,\n                    <jats:bold>9<\/jats:bold>\n                    , and\n                    <jats:bold>10<\/jats:bold>\n                    , particularly with regard to their safety and efficacy.\n                  <\/jats:p>","DOI":"10.1111\/cbdd.70234","type":"journal-article","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T12:23:32Z","timestamp":1767443012000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti\u2010Inflammatory and Antidiabetic Metabolites From\n                    <i>Mitragyna diversifolia<\/i>\n                    : In\u00a0Vitro, Phytochemical, and Computational Studies"],"prefix":"10.1111","volume":"107","author":[{"given":"Jing","family":"Lu","sequence":"first","affiliation":[{"name":"Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences  Kunming China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanlei","family":"Wang","sequence":"additional","affiliation":[{"name":"Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences  Kunming China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences  Kunming China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Zhao","sequence":"additional","affiliation":[{"name":"Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuelin","family":"Chen","sequence":"additional","affiliation":[{"name":"Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuping","family":"Chen","sequence":"additional","affiliation":[{"name":"Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences  Kunming China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4332-9338","authenticated-orcid":false,"given":"Yumei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences  Kunming China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.softx.2015.06.001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/414813a"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1875\u20105364(14)60096\u20100"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2013.10.002"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf201335g"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29071483"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.05.021"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2024.142730"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2024.104714"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0031\u20109422(02)00541\u20101"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3329\/bjp.v4i2.2801"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11130\u2010023\u201001123\u20100"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0031\u20109422(01)00426\u20105"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25194424"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5726"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.107.034447"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13765\u2010024\u201000873\u2010y"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12257\u2010013\u20100173\u2010z"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-91707-0.00001-2"},{"issue":"1","key":"e_1_2_9_21_1","first-page":"32","article-title":"Phytochemical Studies on Lonicerae Flos (1) \u2010 Isolation of Iridoid Glycosides and Other Constituents","volume":"16","author":"Lee E. 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