{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T09:09:58Z","timestamp":1780304998002,"version":"3.54.0"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Pediatric asthma is a common chronic condition with several pathological features, including airway inflammation, remodeling, and oxidative stress. Rutaecarpine (RUT), a bioactive alkaloid, exhibits therapeutic efficacy against various allergic diseases. However, its roles in asthma and the underlying molecular mechanisms remain elusive. In this study, we established an ovalbumin (OVA)\u2010induced mouse model of asthma. The results showed that compared with the OVA\u2010challenged group, treatment with RUT (10 and 20\u2009mg\/kg) reduced lung tissue inflammatory scores by 37.5% and 50.0%, respectively. Additionally, RUT suppressed the production of interleukin (IL)\u20104, IL\u20105, and IL\u201013, and decreased the counts of total cells, eosinophils, macrophages, neutrophils, and lymphocytes in bronchoalveolar lavage fluid. Regarding airway remodeling, RUT downregulated the mRNA and protein expression of \u03b1\u2010smooth muscle actin and type I collagen. Furthermore, periodic acid\u2010Schiff staining showed that RUT ameliorated OVA\u2010induced mucus hypersecretion. RUT treatment also exhibited a protective effect on OVA\u2010induced oxidative damage in lung tissues. Mechanistically, RUT suppressed OVA\u2010induced activation of the nuclear factor\u2010kappa B (NF\u2010\u03baB) pathway. Collectively, RUT attenuated inflammation, airway remodeling, and oxidative stress in OVA\u2010induced asthmatic mice by inhibiting the NF\u2010\u03baB pathway, highlighting its potential as an adjunct therapy for pediatric asthma and providing a theoretical basis for future clinical translation.<\/jats:p>","DOI":"10.1111\/cbdd.70275","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T05:02:13Z","timestamp":1773032533000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Rutaecarpine Attenuates Ovalbumin\u2010Induced Asthma in Mice by Regulating the\n                    <scp>NF<\/scp>\n                    \u2010\n                    <scp>\u03baB<\/scp>\n                    Pathway"],"prefix":"10.1111","volume":"107","author":[{"given":"Kongbo","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pediatric Respiratory Medicine Nanyang Central Hospital (Nanyang 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